Paracetamol / Caffeine Brillpharma (Ireland) (Paracetamol, Caffeine)

Paracetamol reduces pain and fever by centrally inhibiting cyclooxygenase enzymes, which lowers prostaglandin production in the brain. Caffeine blocks adenosine receptors, stimulating the central nervous system and causing modest vasoconstriction. This caffeine‑mediated stimulation enhances the analgesic effect of paracetamol, leading to faster and sometimes more complete pain relief.

The specific dose is determined by a qualified prescriber based on the individual’s age, weight, clinical condition and any concomitant medicines. Healthcare professionals follow local prescribing guidelines for paracetamol‑caffeine combinations, and patients should always follow the dosage instructions provided on the label or by their clinician.

Safety data for the combined product in pregnancy and lactation are limited. It should only be used when clearly needed and after a risk‑benefit assessment by a healthcare professional. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative options with their doctor.

To place an order, visit the product page on gnhindia.com, enter the required quantity and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Paracetamol alone provides analgesic and antipyretic effects, but the addition of caffeine can increase the speed and magnitude of pain relief, especially for headache and migraine. Compared with non‑steroidal anti‑inflammatory drugs such as ibuprofen, the combination has a lower risk of gastrointestinal irritation but does not possess anti‑inflammatory activity.

Store the tablets at ambient temperature below 25 °C, in their original packaging, and protect them from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. Do not use the product if the packaging is damaged or if the tablets appear discoloured.

The product is taken orally with a full glass of water. It may be taken with or without food, according to the prescriber’s advice. Swallow the tablet whole; do not crush, chew or split unless specifically instructed by a healthcare professional.

Serious adverse reactions, although rare, include severe allergic responses such as anaphylaxis, liver injury that can progress to hepatic failure, and life‑threatening skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs of rash, jaundice, dark urine, persistent nausea or any symptoms of an allergic reaction.

The combination should be avoided in individuals with known hypersensitivity to paracetamol, caffeine or any excipients, in patients with severe liver impairment, and in those who are taking other medicines containing paracetamol to avoid accidental overdose. Caution is also advised for people with uncontrolled hypertension, cardiac arrhythmias or certain psychiatric conditions due to the stimulant component.