Product image of Paracetamol / Caffeine Bristol Laboratories (Paracetamol, Caffeine) supplied by GNH India

Paracetamol / Caffeine Bristol Laboratories

Active Ingredient:
Paracetamol, Caffeine
Origin:
EU

Paracetamol / Caffeine Bristol Laboratories (Paracetamol, Caffeine)

Paracetamol, the active ingredient in Paracetamol / Caffeine Bristol Laboratories, is a Analgesic/Stimulant presented as an oral tablet for oral use. It is used to relieve mild to moderate pain and reduce fever in adults and children when appropriate.
GNH India supplies Paracetamol / Caffeine Bristol Laboratories as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bristol Laboratories Limited

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Indications & Clinical Uses

Paracetamol combined with caffeine acts on pain and fever pathways to provide enhanced relief.

  • Headache: reduces intensity of tension‑type and mild migraine headaches.
  • Fever: lowers elevated body temperature associated with infections or inflammation.
  • Post‑operative pain: alleviates mild to moderate pain after minor surgical procedures.
  • Musculoskeletal pain: eases discomfort from strains, sprains and minor injuries.

How It Works

  • Paracetamol exerts its analgesic and antipyretic effects primarily by inhibiting central cyclo‑oxygenase enzymes, reducing prostaglandin synthesis in the brain. Caffeine acts as a non‑selective adenosine‑receptor antagonist, increasing neuronal firing and enhancing the analgesic effect of paracetamol while also providing mild stimulant activity.

Side Effects

Paracetamol/caffeine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild stomach upset after ingestion.
  • Insomnia: difficulty sleeping due to caffeine content.
  • Increased heart rate: mild tachycardia in sensitive individuals.
  • Anxiety: heightened nervousness or jitteriness.
  • Dizziness: transient light‑headedness.
  • Stomach upset: mild dyspepsia or abdominal discomfort.

Serious or Rare Side Effects

  • Allergic reactions: rash, itching, swelling, or angioedema.
  • Liver toxicity: elevated transaminases or hepatic failure with overdose.
  • Severe hypertension: marked increase in blood pressure.
  • Cardiac arrhythmia: irregular heart rhythm in predisposed patients.
  • Seizures: rare occurrence, especially with high caffeine intake.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane reaction.

Precautions & Warnings

Paracetamol/caffeine should be used with attention to patient‑specific factors.

  • Liver function assessment: avoid in severe hepatic impairment.
  • Alcohol consumption: limit intake as combined use increases liver risk.
  • Pregnancy: use only if clearly needed and prescribed by a healthcare professional.
  • Caffeine intake: monitor total daily caffeine from all sources to avoid overstimulation.
  • Renal impairment: adjust use in patients with significant kidney disease.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Paracetamol/caffeine can interact with several medicines, requiring caution.

Major Interactions (Avoid)

  • Alcohol: synergistic hepatotoxicity.
  • Warfarin: may enhance anticoagulant effect, increasing bleeding risk.
  • Carbamazepine: induces metabolism, reducing analgesic efficacy.
  • Rifampicin: accelerates clearance of paracetamol.
  • Other hepatotoxic drugs: combined liver stress.

Moderate Interactions (Monitor Closely)

  • Other stimulants (e.g., pseudoephedrine): may cause excessive nervous system stimulation.
  • MAO inhibitors: potential hypertensive response.
  • SSRIs: possible increase in bleeding tendency.
  • Antihypertensives: caffeine may diminish blood‑pressure‑lowering effect.
  • Antidiabetic agents: caffeine can affect glucose control.

Frequently Asked Questions

Paracetamol / Caffeine is indicated for the relief of mild to moderate pain such as headache, fever, postoperative discomfort and musculoskeletal aches. The caffeine component enhances the analgesic effect of paracetamol, providing faster and more effective symptom control.

Paracetamol reduces pain and fever by inhibiting central cyclo‑oxygenase enzymes, which lowers prostaglandin production in the brain. Caffeine blocks adenosine receptors, increasing neuronal activity and boosting the analgesic effect of paracetamol while also providing a mild stimulant effect.

The appropriate dose is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition and other medications. Dosage instructions should always follow the prescriber’s recommendation and the product label.

Paracetamol is generally considered safe in pregnancy when used at recommended doses, but caffeine intake should be limited. Breastfeeding mothers should consult their doctor, as caffeine can pass into breast milk and may affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The addition of caffeine to paracetamol enhances analgesic efficacy, often providing faster pain relief and allowing lower doses of paracetamol for the same effect. Plain paracetamol lacks this stimulant boost and may be less effective for certain types of headache.

Store the tablets below 25 °C in a dry place, keeping them in the original packaging to protect from moisture. Avoid exposure to high temperatures and direct sunlight to maintain product stability.

The product is supplied as oral tablets and should be taken with water. It is usually administered with or without food, as directed by the prescriber, and the dosage interval is based on the individual treatment plan.

Serious risks include severe liver injury from overdose, allergic reactions such as rash or angioedema, and rare but serious cardiovascular effects like hypertension or arrhythmias, especially in patients sensitive to caffeine.

Patients with known severe liver disease, hypersensitivity to paracetamol or caffeine, uncontrolled hypertension, or those taking interacting medications such as certain anticoagulants or enzyme‑inducing drugs should avoid this combination unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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