Product image of Paracetamol/Codeine Accord (Paracetamol, Codeine Phosphate Hemihydrate) supplied by GNH India

Paracetamol/Codeine Accord

Active Ingredient:
Paracetamol, Codeine Phosphate Hemihydrate
Origin:
EU

Paracetamol/Codeine Accord (Paracetamol, Codeine Phosphate Hemihydrate)

Paracetamol, the active ingredient in Paracetamol/Codeine Accord, is an analgesic presented as a combination tablet for oral use. It treats mild to moderate pain and reduces fever in adults. Codeine, the second active ingredient, is an opioid analgesic that enhances pain relief when combined with paracetamol.

GNH India supplies Paracetamol/Codeine Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare France Sas

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Indications & Clinical Uses

Paracetamol/Codeine Accord is used for pain relief in several clinical contexts:

  • Dental pain: Provides effective relief of postoperative dental discomfort.
  • Musculoskeletal pain: Reduces pain associated with strains, sprains and minor injuries.
  • Headache and migraine: Alleviates moderate headache symptoms when other treatments are insufficient.

How It Works

  • Paracetamol works by inhibiting central cyclooxygenase enzymes, reducing prostaglandin synthesis and lowering the pain‑threshold set point in the brain. Codeine is a pro‑drug that is metabolised to morphine, which binds to µ‑opioid receptors in the central nervous system, producing analgesia and modest cough suppression. The combination yields additive analgesic effects without significantly increasing anti‑inflammatory activity.

Side Effects

Paracetamol/Codeine Accord may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Constipation: reduced bowel movements.
  • Drowsiness: feeling of sleepiness or reduced alertness.
  • Dizziness: light‑headed sensation.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Respiratory depression: slowed breathing, especially at higher doses.
  • Hepatotoxicity: liver injury from excessive paracetamol exposure.
  • Allergic reactions: rash, itching, swelling or anaphylaxis.
  • Dependence or misuse: potential for opioid‑related dependence.
  • Severe hypotension: marked drop in blood pressure.

Precautions & Warnings

Paracetamol/Codeine Accord should be used with caution in specific situations:

  • Liver disease: avoid exceeding recommended paracetamol limits.
  • Renal impairment: monitor kidney function regularly.
  • Respiratory conditions: use carefully in patients with asthma or COPD.
  • Concomitant CNS depressants: may increase sedation and respiratory risk.
  • Pregnancy and lactation: limit use to situations where benefits outweigh risks.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol/Codeine Accord can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • MAO inhibitors: risk of severe hypertension or serotonin syndrome.
  • Benzodiazepines: additive central nervous system depression.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): reduce conversion of codeine to morphine, lowering analgesic effect.

Moderate Interactions (Monitor Closely)

  • Alcohol: increases risk of liver toxicity and sedation.
  • Anticoagulants (e.g., warfarin): may enhance bleeding risk.
  • Antihistamines: can potentiate drowsiness.
  • Diuretics: may affect renal clearance of paracetamol.

Frequently Asked Questions

Paracetamol/Codeine Accord is an oral analgesic combination indicated for the short‑term relief of mild to moderate pain such as dental pain, musculoskeletal aches, and tension‑type headaches when other non‑opioid options are insufficient.

Paracetamol reduces pain by inhibiting central cyclooxygenase enzymes, while codeine is metabolised to morphine, which activates µ‑opioid receptors in the brain and spinal cord. Together they provide additive analgesia without significant anti‑inflammatory action.

The prescribed dose is determined by the treating clinician based on the patient’s age, weight, pain severity and medical history. Healthcare professionals adjust the amount and frequency to stay within safe limits for both paracetamol and codeine.

Use during pregnancy or lactation is permitted only when the expected benefit outweighs potential risk. Codeine crosses the placenta and appears in breast milk, so clinicians usually limit exposure and monitor the infant for sedation or respiratory effects.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with paracetamol alone, the addition of codeine offers stronger analgesia for moderate pain but introduces opioid‑related risks such as dependence and respiratory depression. It is less potent than stronger opioids like morphine, making it suitable for short‑term use.

Store the tablets below 25 °C in their original container, protecting them from moisture, heat and direct sunlight. Keep out of reach of children and dispose of any damaged or expired product according to local regulations.

The medication is taken orally, usually with a glass of water. It may be taken with or without food, but taking it with food can reduce stomach upset. Patients should follow the prescribing clinician’s instructions regarding timing and frequency.

Serious risks include respiratory depression, especially in opioid‑naïve individuals or when combined with other depressants, and liver injury from excessive paracetamol intake. Allergic reactions and opioid dependence are also important safety concerns.

Individuals with known hypersensitivity to paracetamol, codeine or any excipients, those with severe respiratory disorders, uncontrolled asthma, or significant liver impairment should avoid this product. It is also contraindicated in patients taking MAO inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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