Paracetamol/Codeine Accord (Paracetamol, Codeine Phosphate Hemihydrate)

Paracetamol/Codeine Accord is used for pain relief in several common clinical situations:

• Dental pain: Provides effective relief of post‑extraction or procedural discomfort.
• Musculoskeletal pain: Reduces pain associated with strains, sprains and low‑back injuries.
• Headache and migraine relief: Alleviates moderate headache symptoms when simpler analgesics are insufficient.

• Paracetamol/Codeine Accord combines paracetamol, which inhibits central cyclooxygenase enzymes to lower prostaglandin synthesis and reduce pain signalling, with codeine phosphate hemihydrate, an opioid agonist that binds to μ‑opioid receptors in the central nervous system, producing analgesia and a modest antitussive effect.

Paracetamol/Codeine Accord may cause a range of adverse reactions.

Common Side Effects

• Nausea: Mild to moderate stomach upset.
• Constipation: Reduced bowel movements.
• Drowsiness: Feeling of sleepiness or reduced alertness.
• Dizziness: Light‑headed sensation.
• Dry mouth: Reduced salivation.
• Sweating: Increased perspiration.

Serious or Rare Side Effects

• Respiratory depression: Slowed breathing, especially at higher doses.
• Allergic reactions: Rash, itching, swelling or anaphylaxis.
• Hepatotoxicity: Liver injury from excessive paracetamol exposure.
• Dependence or misuse potential: Risk of opioid‑related dependence.
• Severe hypotension: Marked drop in blood pressure.
• Seizures: Rare occurrence, particularly with overdose.

When using Paracetamol/Codeine Accord, consider the following safety measures:

• Assess liver function: Check baseline hepatic health before initiating therapy.
• Limit alcohol intake: Reduce consumption to lower risk of liver injury.
• Monitor for sedation: Advise patients not to operate machinery.
• Evaluate renal risk: Use caution in patients with impaired kidney function.
• Review concomitant CNS depressants: Adjust therapy if other sedatives are used.
• Store at ambient temperature: Keep tablets in the original container, protected from moisture and direct sunlight.

Paracetamol/Codeine Accord can interact with several medicines. Review strong 

Major Interactions (Avoid)

• CYP 3‑4   

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