Paracetamol & Codeine Accord-Uk

Active Ingredient:: Paracetamol, Codeine Phosphate Hemihydrate
Origin:: EU

Paracetamol & Codeine Accord-Uk (Paracetamol, Codeine Phosphate Hemihydrate)

International sale not permitted. Listed for the domestic market and B2B only.

Paracetamol and Codeine Phosphate Hemihydrate, the active ingredient in Paracetamol & Codeine Accord-Uk, is a combination analgesic presented as a tablet for oral use. It provides pain relief and reduces fever in adults requiring stronger analgesia than paracetamol alone.

GNH India supplies Paracetamol & Codeine Accord-Uk as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord-Uk Limited

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Indications & Clinical Uses

Paracetamol & Codeine Accord-Uk is used to manage moderate to severe pain and associated fever across several clinical situations.

Acute postoperative pain: provides stronger analgesia than paracetamol alone, facilitating recovery.
Dental pain: reduces pain intensity after dental procedures.
Musculoskeletal pain: alleviates pain from strains, sprains, and arthritis flares.
Fever: lowers elevated body temperature when analgesic effect is also required.

How It Works

Paracetamol acts centrally by inhibiting cyclooxygenase enzymes, decreasing prostaglandin synthesis, which yields analgesic and antipyretic effects. Codeine phosphate hemihydrate is a prodrug converted by hepatic metabolism to morphine, which binds to μ‑opioid receptors in the central nervous system, enhancing analgesia through inhibition of pain signal transmission.

Side Effects

Paracetamol & Codeine Accord-Uk may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

Nausea: mild to moderate stomach upset.
Drowsiness: increased sleepiness or fatigue.
Constipation: reduced bowel movements.
Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

Respiratory depression: slowed breathing, especially at higher doses.
Allergic reactions: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

Before using Paracetamol & Codeine Accord-Uk, consider the following precautions to ensure safe therapy.

Assess liver function: avoid use in severe hepatic impairment.
Avoid in respiratory disorders: patients with asthma or COPD may experience worsening.
Monitor for dependence: codeine carries risk of opioid tolerance and addiction.
Use cautiously in the elderly: increased sensitivity to sedative effects.
Store at ambient temperature: keep below 25°C in the original container, protect from moisture.

Avoid Interactions

Paracetamol & Codeine Accord-Uk can interact with other medicines; some combinations should be avoided while others require close monitoring.

Major Interactions (Avoid)

Other central nervous system depressants (e.g., benzodiazepines, alcohol): may enhance sedation and respiratory depression.
Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): reduce conversion of codeine to morphine, decreasing analgesic effect.

Moderate Interactions (Monitor Closely)

Warfarin: may increase bleeding risk; monitor INR.
Anticholinergic agents: may worsen constipation.
Monoamine oxidase inhibitors: potential for serotonin syndrome when combined with other serotonergic drugs.

Frequently Asked Questions

Paracetamol & Codeine Accord-Uk is a prescription‑only combination analgesic indicated for the relief of moderate to severe pain and for the reduction of fever when a stronger effect than paracetamol alone is required.

Paracetamol reduces pain and fever by inhibiting central cyclooxygenase enzymes, lowering prostaglandin production. Codeine phosphate hemihydrate is metabolised to morphine, which activates μ‑opioid receptors in the brain and spinal cord, diminishing the perception of pain.

The appropriate dose is determined by the prescribing clinician based on the patient’s age, weight, pain severity, and overall health. No fixed dosing regimen is provided here; patients should follow the prescriber’s instructions exactly.

Safety in pregnancy and lactation has not been fully established. Healthcare professionals should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing patients.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑opioid analgesics such as ibuprofen, the addition of codeine provides stronger pain relief but introduces opioid‑related risks like dependence and respiratory depression. It is generally chosen when paracetamol or NSAIDs alone are insufficient.

Store the tablets at ambient temperature, below 25 °C, in the original packaging. Keep them away from moisture and direct sunlight to maintain potency and prevent degradation.

The medication is taken orally, usually as a whole tablet with a glass of water. It should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare professional.

The most critical concerns are respiratory depression, especially in high‑dose or opioid‑naïve patients, and the potential for dependence, tolerance and abuse. Severe allergic reactions, such as anaphylaxis, also require immediate medical attention.

Patients with known hypersensitivity to paracetamol, codeine or any excipients, those with severe hepatic impairment, uncontrolled respiratory disorders, or a history of opioid addiction should avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 13 Oct 2026

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International sale not permitted. Listed for the domestic market and B2B only.

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