Paracetamol, Codeine And Caffeine Kent Pharma Uk (Paracetamol, Caffeine, Codeine Phosphate Hemihydrate)

Paracetamol, Codeine and Caffeine is a combination analgesic that acts on pain‑related pathways and fever mechanisms.

• Dental pain: provides relief of moderate dental discomfort.
• Musculoskeletal pain: reduces pain associated with strains, sprains and low‑back tension.
• Headache and migraine‑type pain: alleviates tension‑type headache symptoms.
• Fever: helps lower elevated body temperature in adults.
• Post‑operative pain: assists in managing pain after minor surgical procedures.

• The formulation combines paracetamol, which inhibits central cyclooxygenase activity to reduce prostaglandin synthesis, with codeine phosphate hemihydrate, an opioid agonist that binds to µ‑mu‑receptors in the CNS. Caffeine acts as a central nervous system stimulant, enhancing analgesic absorption and potency. Together, these actions provide synergistic pain relief and antipyretic effects.

Paracetamol, Codeine and Caffeine may cause a range of adverse reactions.

Common Side Effects

• Nausea and vomiting
• Drowsiness or mild sedation
• Dizziness
• Constipation
• Headache
• Increased heart rate

Serious or Rare Side Effects

• Respiratory depression
• Severe allergic reaction (anaphylaxis)
• Hepatotoxicity with overdose
• Opioid dependence or withdrawal symptoms
• Seizures
• Low blood pressure (hypotension)

When using this combination product, certain safety measures should be observed.

• Dose limitation: adhere to the maximum daily paracetamol amount to avoid liver injury.
• Opioid caution: patients with a history of substance misuse 
• Pregnancy: limit use to situations where benefits outweigh 
• Breastfeeding: consider potential infant exposure through milk.
• Concomitant CNS depressants: monitor for enhanced sedation.
• Store at ambient temperature: keep in the original packaging, protect from moisture and light.