Paracetamol + Codeine Apap Us Pharmacia

Active Ingredient:: Paracetamol, Codeine Phosphate Hemihydrate
Origin:: EU

Paracetamol + Codeine Apap Us Pharmacia (Paracetamol, Codeine Phosphate Hemihydrate)

International sale not permitted. Listed for the domestic market and B2B only.

Paracetamol, the active ingredient in Paracetamol + Codeine Apap Us Pharmacia, is an analgesic combination presented as an oral tablet for systemic use. It provides pain relief and reduces fever in adults and children when prescribed by a qualified healthcare professional.

GNH India supplies Paracetamol + Codeine Apap Us Pharmacia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Including temperature‑controlled shipping where required.

Manufacturer / TM Owner

Us Pharmacia Sp. Z O.O.

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Indications & Clinical Uses

Paracetamol + Codeine is used to manage pain and fever by acting on central pain pathways and thermoregulatory centers.

Moderate to severe acute pain: provides analgesia when non‑opioid analgesics alone are insufficient.
Post‑operative pain: helps control pain following surgical procedures.
Fever: reduces elevated body temperature when antipyretic effect is needed.

How It Works

Paracetamol exerts its antipyretic and analgesic effects primarily through central inhibition of cyclooxygenase enzymes, decreasing prostaglandin synthesis in the brain. Codeine phosphate hemihydrate is a pro‑drug converted to morphine, which binds to µ‑opioid receptors in the central nervous system, altering pain perception and providing additional analgesia.

Side Effects

Paracetamol + Codeine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

Nausea
Constipation
Drowsiness
Dizziness
Vomiting
Dry mouth

Serious or Rare Side Effects

Respiratory depression
Severe allergic reactions (e.g., rash, angioedema)
Hepatotoxicity, especially with high paracetamol doses
Seizures
Hypotension
Dependence or addiction potential

Precautions & Warnings

When prescribing or dispensing Paracetamol + Codeine, consider the following precautions to ensure safe use.

Liver function assessment: avoid use in patients with severe hepatic impairment or chronic alcohol abuse.
Alcohol avoidance: advise patients to limit or abstain from alcohol while taking the product.
Respiratory monitoring: use caution in individuals with asthma or other respiratory disorders.
Elderly caution: start with the lowest effective dose and monitor for sedation or falls.
Concomitant CNS depressants: avoid or closely monitor use with benzodiazepines, antihistamines, or alcohol.
Store at ambient temperature: keep below 25 °C in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Paracetamol + Codeine can interact with several medicines; some combinations should be avoided while others require careful monitoring.

Major Interactions (Avoid)

Other opioids or strong CNS depressants (e.g., benzodiazepines, alcohol) – increased risk of respiratory depression.
Monoamine oxidase inhibitors – may precipitate serotonin syndrome.
CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) – can raise codeine levels and risk toxicity.
Hepatotoxic drugs (e.g., isoniazid, high‑dose acetaminophen) – increase risk of liver injury.
Mixed opioid preparations – may lead to cumulative opioid effects.

Moderate Interactions (Monitor Closely)

CYP3A4 inducers (e.g., rifampicin, carbamazepine) – may reduce analgesic efficacy.
Anticholinergic agents – may worsen constipation.
Diuretics – may enhance hypotensive effects.
NSAIDs – combined use can increase hepatic load.
Antihistamines – may add to sedation.

Frequently Asked Questions

Paracetamol + Codeine is indicated for the relief of moderate to severe pain and for the reduction of fever when a single agent is insufficient. It is commonly prescribed after surgery, for injury‑related pain, or when an antipyretic effect is required.

Paracetamol reduces pain and fever by inhibiting central cyclooxygenase enzymes, lowering prostaglandin production in the brain. Codeine is metabolised to morphine, which binds to µ‑opioid receptors in the central nervous system, enhancing analgesia and altering pain perception.

The appropriate dose of Paracetamol + Codeine is determined by the prescribing clinician based on the patient’s age, weight, severity of pain, and overall health status. Patients should follow the prescriber’s instructions and never exceed the recommended amount.

Paracetamol alone is generally considered safe in pregnancy when used at recommended doses, but codeine crosses the placenta and may affect the newborn. Use during pregnancy or lactation only if clearly indicated and after a risk‑benefit assessment by a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑opioid analgesics such as ibuprofen, Paracetamol + Codeine adds an opioid component, offering stronger relief for moderate to severe pain but also carrying a higher risk of opioid‑related side effects. Pure codeine provides opioid effects without the antipyretic benefit of paracetamol.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect them from moisture, direct sunlight and excessive heat. Keep out of reach of children and do not use after the expiry date.

Paracetamol + Codeine is taken orally, usually with a glass of water. It may be taken with or without food, but taking it with food can reduce gastrointestinal discomfort. The exact timing and frequency should follow the prescriber’s directions.

Serious risks include respiratory depression, especially in patients with underlying lung disease or when combined with other depressants; severe allergic reactions; hepatotoxicity from excessive paracetamol exposure; and the potential for dependence or addiction associated with the codeine component.

Paracetamol + Codeine should be avoided in individuals with severe hepatic impairment, known hypersensitivity to either component, significant respiratory depression, or those taking monoamine oxidase inhibitors. It is also contraindicated in children under the age specified by local regulations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 13 Oct 2026

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International sale not permitted. Listed for the domestic market and B2B only.

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