Paracetamol & Codeine Aspar Pharmaceuticals

Active Ingredient:: Paracetamol, Codeine Phosphate Hemihydrate
Origin:: EU

Paracetamol & Codeine Aspar Pharmaceuticals (Paracetamol, Codeine Phosphate Hemihydrate)

International sale not permitted. Listed for the domestic market and B2B only.

Paracetamol and Codeine Phosphate Hemihydrate, the active ingredient in Paracetamol & Codeine Aspar Pharmaceuticals, is an analgesic presented as an oral dosage form for oral use. It provides relief of mild to moderate pain and reduces fever in adults and children when prescribed.

GNH India supplies Paracetamol & Codeine Aspar Pharmaceuticals as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing, regulatory support and timely delivery across multiple regions. The company adheres to stringent quality standards to ensure product integrity.

Manufacturer / TM Owner

Aspar Pharmaceuticals Limited

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Indications & Clinical Uses

Paracetamol and Codeine act on pain and fever pathways to provide symptomatic relief.

Mild to moderate pain: reduces pain intensity in conditions such as headache, dental pain, musculoskeletal discomfort, or postoperative pain.
Fever: lowers elevated body temperature associated with infections or inflammatory conditions.
Cough: suppresses the cough reflex through the opioid component, useful in short‑term management of non‑productive cough.
Migraine (adjunct): provides analgesic effect that may complement specific migraine therapies.

How It Works

Paracetamol exerts central analgesic and antipyretic actions by inhibiting brain cyclooxygenase enzymes and modulating the endocannabinoid system, thereby reducing prostaglandin synthesis and resetting temperature regulation. Codeine phosphate hemihydrate is metabolised by hepatic CYP2D6 to morphine, which binds μ‑opioid receptors in the central nervous system, producing analgesia, sedation and cough suppression. The combination yields synergistic pain relief.

Side Effects

Paracetamol and Codeine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

Nausea: feeling of stomach upset or urge to vomit.
Dizziness: light‑headed sensation or loss of balance.
Constipation: reduced bowel movements or hard stools.
Drowsiness: increased sleepiness or reduced alertness.
Dry mouth: reduced salivation causing throat discomfort.

Serious or Rare Side Effects

Respiratory depression: slowed or shallow breathing that can be life‑threatening.
Severe allergic reaction: rash, itching, swelling, or anaphylaxis.
Hepatic injury: signs of liver damage such as jaundice or elevated enzymes.
Dependence or abuse potential: risk of developing opioid use disorder with prolonged use.
Opioid‑induced constipation leading to bowel obstruction (rare).

Precautions & Warnings

When prescribing Paracetamol & Codeine, clinicians should consider several safety precautions to minimise risk.

Assess liver function: avoid use in patients with severe hepatic impairment or active liver disease.
Evaluate renal function: dose adjustment may be needed for severe renal insufficiency.
Screen for opioid sensitivity: avoid in individuals with known hypersensitivity to codeine or other opioids.
Limit concurrent CNS depressants: caution when used with alcohol, benzodiazepines, or antihistamines.
Monitor for dependence: use the lowest effective dose for the shortest duration to reduce abuse risk.
Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol & Codeine can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

MAO inhibitors: risk of severe serotonin syndrome and hypertensive crisis.
Other opioids or strong CNS depressants: additive respiratory depression.
Alcohol: enhances sedative effects and risk of liver toxicity.
CYP2D6 inhibitors (e.g., fluoxetine, quinidine): reduce conversion of codeine to morphine, decreasing analgesia.

Moderate Interactions (Monitor Closely)

Antihistamines: may increase drowsiness and dizziness.
Benzodiazepines: can potentiate sedation and respiratory effects.
Antidepressants (SSRIs, SNRIs): may increase risk of serotonin syndrome.
Anticoagulants (warfarin): paracetamol may enhance anticoagulant effect, requiring INR monitoring.

Frequently Asked Questions

Paracetamol & Codeine is prescribed to relieve mild to moderate pain such as headache, dental or musculoskeletal pain, and to reduce fever. The combination may also be used short‑term to suppress a non‑productive cough when indicated by a healthcare professional.

Paracetamol acts centrally by inhibiting cyclooxygenase enzymes and influencing the endocannabinoid system, which lowers prostaglandin production and reduces pain and temperature. Codeine is a pro‑drug converted by the liver into morphine, which binds to μ‑opioid receptors in the brain and spinal cord, providing analgesia, sedation and cough suppression.

The appropriate dose is determined by the prescribing clinician based on the patient’s age, weight, clinical condition and other medications. Healthcare providers follow local prescribing guidelines and regulatory limits for both paracetamol and codeine components.

Safety data are limited. Paracetamol is generally considered acceptable in pregnancy at recommended doses, but codeine crosses the placenta and may cause neonatal respiratory depression. Breastfeeding mothers should use the product only if the benefit outweighs the risk and under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑opioid analgesics such as ibuprofen, the addition of codeine provides stronger relief for moderate pain but introduces opioid‑related risks like dependence and respiratory depression. The combination is useful when paracetamol alone is insufficient, while NSAIDs may be preferred for inflammatory pain without opioid exposure.

Store the product at ambient temperature below 25 °C, in its original packaging, protected from moisture, heat and direct sunlight. Keep out of reach of children and do not use after the expiry date printed on the label.

The medication is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the specific instructions provided by their prescriber or pharmacist.

The most critical risks include respiratory depression, especially when combined with other CNS depressants; severe allergic reactions; hepatic injury from excessive paracetamol; and the potential for dependence, tolerance or misuse of the opioid component.

Patients with known hypersensitivity to paracetamol, codeine or any excipients; those with severe respiratory depression, uncontrolled asthma, or significant hepatic or renal impairment should avoid the product. It is also contraindicated in children under the age limits set by local regulations for codeine‑containing medicines.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 13 Oct 2026

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International sale not permitted. Listed for the domestic market and B2B only.

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