Paracetamol Codeine Extra Zentiva

Active Ingredient:: Paracetamol, Caffeine, Codeine Phosphate Hemihydrate
Origin:: EU

Paracetamol Codeine Extra Zentiva (Paracetamol, Caffeine, Codeine Phosphate Hemihydrate)

International sale not permitted. Listed for the domestic market and B2B only.

Paracetamol, the active ingredient in Paracetamol Codeine Extra Zentiva, is a combination analgesic presented as an oral tablet for oral use. It is indicated for the relief of mild to moderate pain, fever and headache in adult patients.
GNH India supplies Paracetamol Codeine Extra Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva Pharma Uk Limited

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Indications & Clinical Uses

Paracetamol Codeine Extra Zentiva is used to manage pain and fever through its analgesic and antipyretic actions.

Mild to moderate pain: provides relief of tension, musculoskeletal and dental pain.
Fever: reduces elevated body temperature associated with infections.
Headache: alleviates tension‑type and migraine‑associated headaches.

How It Works

Paracetamol inhibits cyclo‑oxygenase enzymes, reducing prostaglandin synthesis for analgesic and antipyretic effects. Codeine phosphate hemihydrate acts as a µ‑opioid receptor agonist, modulating pain pathways in the central nervous system. Caffeine antagonises adenosine receptors, enhancing the analgesic potency of paracetamol and codeine and contributing to central stimulation.

Side Effects

Adverse reactions may occur with use of this combination analgesic.

Common Side Effects

Nausea: mild to moderate stomach upset.
Constipation: reduced bowel movements.
Drowsiness: increased sleepiness.
Dizziness: sensation of light‑headedness.
Dry mouth: reduced salivation.
Insomnia: difficulty sleeping, often related to caffeine.

Serious or Rare Side Effects

Respiratory depression: slowed breathing, especially with high opioid doses.
Severe allergic reaction: rash, swelling, or anaphylaxis.
Liver toxicity: elevated enzymes or hepatic injury from paracetamol.
Dependence or abuse potential: risk of opioid dependence.
Seizures: rare neurologic events.
Low blood pressure: hypotension, particularly with concomitant antihypertensives.

Precautions & Warnings

Before prescribing, clinicians should consider safety factors and proper handling.

Liver function assessment: evaluate hepatic status due to paracetamol metabolism.
Respiratory conditions: avoid in patients with severe asthma or COPD.
CNS depressants: use caution when combined with other sedatives.
Addiction risk: monitor for signs of opioid misuse.
Pediatric use: not recommended for children under 12 years.
Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Paracetamol Codeine Extra Zentiva may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

Alcohol: increases risk of liver injury and respiratory depression.
Other opioids: additive sedation and respiratory effects.
MAO inhibitors: may precipitate severe hypotension or serotonin syndrome.
CNS depressants (benzodiazepines, barbiturates): heightened sedation and respiratory risk.
CYP2D6 inhibitors (e.g., quinidine): may reduce codeine conversion to active metabolite.

Moderate Interactions (Monitor Closely)

SSRIs or SNRIs: potential for serotonin syndrome.
Antihistamines: may enhance drowsiness.
Antihypertensives: possible additive blood‑pressure lowering.
Diuretics: may affect renal clearance of paracetamol.

Frequently Asked Questions

Paracetamol Codeine Extra Zentiva is indicated for the relief of mild to moderate pain, reduction of fever, and treatment of headache in adult patients. It combines an analgesic, an opioid, and a stimulant to provide effective symptom control.

Paracetamol reduces pain and fever by inhibiting cyclo‑oxygenase enzymes, lowering prostaglandin production. Codeine acts as a µ‑opioid receptor agonist, modulating pain signals in the central nervous system. Caffeine blocks adenosine receptors, which enhances the analgesic effect of the other two components and adds a mild stimulating effect.

The specific dose and dosing schedule of Paracetamol Codeine Extra Zentiva are determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and overall health. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety of this medication during pregnancy or lactation has not been fully established. Healthcare providers should evaluate the potential benefits against possible risks before prescribing to pregnant or nursing women. In many cases, alternative therapies with established safety profiles are preferred.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑ingredient analgesics, this combination offers enhanced pain relief through synergistic action of paracetamol, codeine, and caffeine. It may provide stronger efficacy than paracetamol alone, while having a lower opioid dose than pure codeine preparations, but it also carries the combined safety considerations of each component.

The product should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keeping the tablets in a dry, tightly sealed container helps maintain their stability and potency.

Paracetamol Codeine Extra Zentiva is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks include respiratory depression, especially when combined with other CNS depressants, severe allergic reactions, liver toxicity from paracetamol overdose, and the potential for dependence or abuse due to the opioid component. Patients should be monitored closely for these events.

Individuals with known hypersensitivity to paracetamol, codeine, caffeine, or any excipients should avoid this product. It is also contraindicated in patients with severe respiratory depression, significant liver disease, or in children under 12 years of age unless specifically prescribed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 14 Oct 2026

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International sale not permitted. Listed for the domestic market and B2B only.

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