Product image of Paracetamol/Codeine Phosphate Hemihydrate Accord (Paracetamol, Codeine Phosphate Hemihydrate) supplied by GNH India

Paracetamol/Codeine Phosphate Hemihydrate Accord

Active Ingredient:
Paracetamol, Codeine Phosphate Hemihydrate
Origin:
EU

Paracetamol/Codeine Phosphate Hemihydrate Accord (Paracetamol, Codeine Phosphate Hemihydrate)

Paracetamol, the active ingredient in Paracetamol/Codeine Phosphate Hemihydrate Accord, is an analgesic presented as a combination tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children when appropriate. GNH India supplies Paracetamol/Codeine Phosphate Hemihydrate Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Paracetamol/Codeine Phosphate Hemihydrate Accord is provided by GNH India, a licensed, GDP‑compliant supplier to hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare Ireland Limited

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Indications & Clinical Uses

Paracetamol/Codeine phosphate hemihydrate is an analgesic that acts on the nociceptive pain pathway and is used for short‑term relief of moderate pain.

  • Dental pain: provides relief of pain following dental procedures or toothache.
  • Musculoskeletal pain: reduces discomfort from strains, sprains and low‑back pain.
  • Post‑operative pain: helps control pain after minor surgical interventions.
  • Headache and migraine: eases moderate headache symptoms when simple analgesics are insufficient.
  • Fever: lowers elevated body temperature associated with infection or inflammation.

How It Works

  • Paracetamol works by inhibiting central cyclo‑oxygenase enzymes, reducing prostaglandin synthesis in the brain, which lowers pain perception and temperature set‑point. Codeine phosphate hemihydrate is a pro‑drug that is metabolised to morphine, binding to µ‑opioid receptors in the central nervous system to diminish pain signalling and produce mild sedation.

Side Effects

Paracetamol/Codeine phosphate hemihydrate may cause a range of adverse reactions, most of which are dose‑dependent and reversible.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Constipation: reduced bowel movements.
  • Drowsiness: feeling of sleepiness.
  • Dizziness: light‑headed sensation.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing, especially at higher doses.
  • Hepatotoxicity: liver injury from excessive paracetamol exposure.
  • Allergic reactions: rash, itching, swelling or anaphylaxis.
  • Seizures: rare occurrence, often linked to overdose.
  • Dependence or withdrawal: potential with prolonged codeine use.

Precautions & Warnings

When using Paracetamol/Codeine phosphate hemihydrate, consider the following safety measures:

  • Liver function monitoring: assess hepatic health before long‑term use.
  • Alcohol use: avoid excessive alcohol as it increases hepatotoxic risk.
  • Opioid sensitivity: assess for heightened response to codeine in opioid‑naïve patients.
  • Pregnancy and lactation: use only if clearly indicated and prescribed.
  • Concomitant CNS depressants: monitor for additive sedation.
  • Store at below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Paracetamol/Codeine phosphate hemihydrate can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): reduce conversion of codeine to morphine, lowering analgesic effect.
  • CNS depressants (benzodiazepines, barbiturates): increase risk of respiratory depression.
  • Alcohol: potentiates hepatotoxicity and sedation.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Antihistamines: can increase drowsiness.
  • Diuretics: may affect renal clearance of paracetamol.

Frequently Asked Questions

Paracetamol/Codeine phosphate hemihydrate Accord is a combination analgesic used for short‑term relief of moderate pain such as dental, musculoskeletal or post‑operative discomfort, and for reducing fever when simpler agents are insufficient.

Paracetamol reduces pain and fever by inhibiting central cyclo‑oxygenase enzymes, which lowers prostaglandin production in the brain, thereby decreasing pain signalling and resetting the hypothalamic temperature set‑point.

The prescribed dose is determined by the treating clinician based on the patient’s age, weight, pain severity and medical history; the prescriber sets the exact regimen.

Use during pregnancy or lactation is only recommended when clearly indicated by a healthcare professional, as codeine crosses the placenta and may affect the newborn, and high‑dose paracetamol can impact liver function.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with single‑ingredient paracetamol, the addition of codeine provides stronger analgesia for moderate pain but introduces opioid‑related risks. It is less potent than stronger opioids such as morphine, offering a balance between efficacy and safety for short‑term use.

Store the tablets at temperatures below 25 °C in the original container, protected from moisture and light. Do not expose to excessive heat or humidity to maintain product stability.

The medication is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the prescriber’s instructions regarding timing and any food considerations.

Serious risks include respiratory depression, especially when combined with other CNS depressants, hepatotoxicity from excessive paracetamol, allergic reactions such as anaphylaxis, and the potential for dependence or withdrawal with prolonged codeine use.

Individuals with severe liver disease, known hypersensitivity to paracetamol or codeine, those taking strong CYP2D6 inhibitors, or patients with a history of opioid dependence should avoid this medication unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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