N – Calmant Iii (Paracetamol, Codeine Phosphate Hemihydrate, Anhydrous Caffeine)

Paracetamol reduces pain and fever by inhibiting central cyclooxygenase enzymes, lowering prostaglandin production. Codeine acts as a μ‑opioid receptor agonist, providing analgesia and cough suppression. Caffeine blocks adenosine receptors, increasing alertness and enhancing the analgesic effect of the other two ingredients.

The appropriate dose of N – Calmant III is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition and response to therapy. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety in pregnancy and lactation has not been fully established for this combination. Healthcare providers should weigh the potential benefits against possible risks and consider alternative therapies when treating pregnant or nursing women.

To request N – Calmant III, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑ingredient paracetamol, the addition of codeine provides stronger opioid‑mediated pain relief, while caffeine can improve onset and potency. This combination may be more effective for moderate pain than paracetamol alone, but it also carries higher risk of opioid‑related side effects.

Store N – Calmant III at room temperature, below 25 °C, in the original packaging. Keep the tablets away from moisture, direct sunlight and excessive heat to maintain product stability.

N – Calmant III is taken orally, usually with a full glass of water. It should be swallowed whole and not chewed or crushed unless directed otherwise by a healthcare professional.

The most serious risks include respiratory depression, especially when combined with other depressants, severe allergic reactions, and potential liver injury from excessive paracetamol exposure. Patients should seek immediate medical attention if they experience difficulty breathing, rash, or signs of liver dysfunction.

Individuals with known hypersensitivity to any component, severe hepatic impairment, uncontrolled respiratory disease, children under 12 years, or those taking other strong opioids or CNS depressants should not use N – Calmant III unless specifically advised by a qualified clinician.