Paracetamol Codeine Zentiva

Active Ingredient:: Paracetamol, Codeine Phosphate
Origin:: EU

Paracetamol Codeine Zentiva (Paracetamol, Codeine Phosphate)

International sale not permitted. Listed for the domestic market and B2B only.

Paracetamol and codeine phosphate, the active ingredients in Paracetamol Codeine Zentiva, are an analgesic combination presented as an oral tablet for systemic use. They act together to relieve moderate to severe pain and to reduce fever, and are prescribed for adults and children under medical supervision.

GNH India supplies Paracetamol Codeine Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets, with reliable logistics and documentation support.

Manufacturer / TM Owner

Zentiva Pharma Uk Limited

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Indications & Clinical Uses

Paracetamol Codeine is used to manage pain and fever in the musculoskeletal and postoperative pathways.

Mild to moderate acute pain: provides effective analgesia when non‑opioid analgesics are insufficient.
Post‑operative pain: reduces pain intensity after surgical procedures.
Dental pain: alleviates discomfort following dental extractions or procedures.
Fever: helps lower elevated body temperature associated with infections.

How It Works

Paracetamol acts centrally to inhibit cyclooxygenase enzymes, reducing prostaglandin synthesis and thereby decreasing pain and fever. Codeine phosphate is a pro‑drug converted to morphine, which binds to μ‑opioid receptors in the central nervous system, modulating pain transmission and producing analgesia and mild sedation. The combination provides synergistic pain relief through complementary pathways. This dual action allows lower doses of each component while maintaining efficacy.

Side Effects

Paracetamol Codeine may cause a range of adverse reactions, varying from common to rare but serious.

Common Side Effects

Nausea
Constipation
Dizziness
Drowsiness
Dry mouth
Sweating

Serious or Rare Side Effects

Respiratory depression
Severe allergic reactions (anaphylaxis)
Hepatotoxicity
Low blood pressure
Seizures
Dependence or abuse potential

Precautions & Warnings

Paracetamol Codeine should be used with caution and according to medical guidance.

Assess liver function: avoid use in patients with severe hepatic impairment.
Avoid in children under 12 years unless prescribed: dose adjustments required.
Monitor for signs of respiratory depression: especially when combined with other CNS depressants.
Use cautiously in patients with a history of substance abuse.
Avoid alcohol consumption: may increase sedation and respiratory risk.
Store at room temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Paracetamol Codeine can interact with other medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

MAO inhibitors: risk of severe reactions.
Other opioid analgesics: additive respiratory depression.
Alcohol: enhances sedative effects.
Benzodiazepines: increased CNS depression.
CYP2D6 inhibitors (e.g., fluoxetine): may alter codeine metabolism.

Moderate Interactions (Monitor Closely)

Antihistamines: may increase drowsiness.
SSRIs/SNRIs: potential for serotonin syndrome.
Diuretics: may affect blood pressure.
Antacids: may affect absorption of paracetamol.
Pregnancy: monitor fetal exposure.

Frequently Asked Questions

Paracetamol Codeine Zentiva is an oral analgesic combination indicated for the relief of moderate to severe pain and for the reduction of fever. It is commonly prescribed for conditions such as postoperative pain, dental pain, musculoskeletal injuries, and febrile illnesses when a single non‑opioid analgesic is insufficient.

Paracetamol reduces pain and fever by inhibiting central cyclooxygenase enzymes, which lowers prostaglandin production. Codeine phosphate is metabolised to morphine, which binds to μ‑opioid receptors in the brain and spinal cord, altering pain perception and providing additional analgesia and mild sedation. The two mechanisms act together to enhance overall pain control.

The appropriate dose of Paracetamol Codeine Zentiva is determined by a qualified prescriber based on the patient’s age, weight, severity of pain, and overall health status. Healthcare professionals consider factors such as liver function, concurrent medications, and risk of opioid‑related side effects before setting a specific dosing regimen.

Paracetamol is generally considered safe for short‑term use during pregnancy when prescribed, but codeine crosses the placenta and may affect the fetus, especially in the third trimester. During breastfeeding, codeine can be transferred to milk and may cause sedation in the infant. Use only under medical supervision and after weighing potential benefits against risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After validation, the sales team provides pricing, availability, shipping details (including any cold‑chain requirements if applicable) and assists with import documentation.

Compared with non‑opioid analgesics such as ibuprofen, Paracetamol Codeine offers stronger pain relief due to the opioid component, making it suitable for moderate to severe pain. However, it carries a higher risk of opioid‑related side effects, dependence, and respiratory depression. The choice between agents depends on pain intensity, patient comorbidities, and the need for anti‑inflammatory effects.

Paracetamol Codeine Zentiva should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in areas with high humidity or direct sunlight. Do not freeze or refrigerate the tablets.

The medication is taken orally, usually with a full glass of water. It may be taken with or without food, but patients should follow the prescriber’s instructions regarding timing relative to meals. Swallow the tablet whole; do not crush, chew, or split it unless specifically directed by a healthcare professional.

The most serious risks include respiratory depression, especially when combined with other CNS depressants, severe allergic reactions such as anaphylaxis, hepatotoxicity from excessive paracetamol exposure, and the potential for dependence or abuse due to the codeine component. Patients should be monitored closely for signs of these adverse events.

Paracetamol Codeine Zentiva is contraindicated in individuals with known hypersensitivity to paracetamol, codeine, or any excipients, in patients with severe hepatic impairment, and in children under 12 years unless specifically prescribed. It should also be avoided in patients taking monoamine‑oxidase inhibitors (MAOIs) or those with a history of significant respiratory disorders without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 14 Oct 2026

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International sale not permitted. Listed for the domestic market and B2B only.

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