Product image of Paracetamol Da (Paracetamol) supplied by GNH India

Paracetamol Da

Active Ingredient:
Paracetamol
Origin:
EU

Paracetamol Da (Paracetamol)

Paracetamol, the active ingredient in Paracetamol Da, is an analgesic presented as an oral tablet for oral use. It relieves mild to moderate pain and reduces fever in adults and children when appropriate dosing is applied and is widely employed in primary care settings.

GNH India supplies Paracetamol Da as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide, ensuring consistent quality and regulatory compliance across markets. The company adheres to stringent manufacturing standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Nederlandse Drogisterij Service B.V.

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Indications & Clinical Uses

Paracetamol Da acts on the prostaglandin pathway to provide analgesic and antipyretic effects.

  • Pain: reduces perception of mild to moderate pain.
  • Fever: lowers elevated body temperature.
  • Headache: alleviates discomfort associated with tension‑type headaches.

How It Works

  • Paracetamol inhibits cyclo‑oxygenase enzymes, primarily COX‑2, within the central nervous system, leading to reduced synthesis of prostaglandins that mediate pain and thermoregulation. This central inhibition diminishes nociceptive signaling and resets the hypothalamic set‑point for body temperature, producing analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Skin rash: transient erythematous eruptions.
  • Abdominal discomfort: occasional mild pain.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Hepatotoxicity: liver injury, especially with overdose or chronic use.
  • Anaphylaxis: rare systemic allergic reaction that can be life‑threatening.

Precautions & Warnings

When using Paracetamol Da, consider the following precautions.

  • Dosage adjustment: reduce dose in patients with hepatic impairment.
  • Alcohol consumption: avoid chronic alcohol use to minimize liver risk.
  • Pregnancy: consult a healthcare professional before use.
  • Concomitant hepatotoxic drugs: monitor liver function when combined with other liver‑affecting medications.
  • Overdose risk: keep out of reach of children and adhere to prescribed limits.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Paracetamol Da may interact with other medicines; awareness of interaction severity is important.

Major Interactions (Avoid)

  • Alcohol: increased risk of liver toxicity.
  • Warfarin: potential enhancement of anticoagulant effect.
  • Isoniazid: heightened hepatotoxic potential.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: may reduce paracetamol efficacy.
  • Phenobarbital: may increase paracetamol metabolism.
  • Phenytoin: may increase metabolic clearance of paracetamol.

Frequently Asked Questions

Paracetamol Da is used to relieve mild to moderate pain and to reduce fever. It is commonly employed for conditions such as headaches, musculoskeletal aches, dental pain, and febrile illnesses, providing symptomatic relief in both adult and pediatric populations when used according to professional guidance.

Paracetamol works by inhibiting central cyclo‑oxygenase enzymes, especially COX‑2, which lowers the production of prostaglandins in the brain. This reduction diminishes the transmission of pain signals and resets the hypothalamic temperature set‑point, resulting in analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

The appropriate dose of Paracetamol Da is determined by the prescribing healthcare professional based on factors such as the patient’s age, weight, clinical condition, and overall health status. Dosage recommendations follow established guidelines, and adjustments may be required for special populations like those with liver impairment.

Safety of Paracetamol Da during pregnancy or lactation should be evaluated by a qualified healthcare provider. While paracetamol is often considered compatible with short‑term use in these periods, the prescriber will weigh potential benefits against any risks and advise on the safest approach for mother and child.

To order Paracetamol Da, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Paracetamol Da differs from non‑steroidal anti‑inflammatory drugs (NSAIDs) such as ibuprofen in that it provides analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity. This makes it a preferred option when gastrointestinal tolerance or platelet inhibition is a concern, though it lacks the anti‑inflammatory benefits of NSAIDs.

Paracetamol Da should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability throughout its shelf life.

Paracetamol Da is administered orally, typically as a tablet that is swallowed whole with water. The exact method of administration, including timing relative to meals, is determined by the prescribing clinician and should follow the instructions provided with the prescription.

The most serious risks associated with Paracetamol Da include severe liver injury (hepatotoxicity), especially in cases of overdose or chronic high‑dose use, and rare hypersensitivity reactions such as Stevens‑Johnson syndrome or anaphylaxis. Prompt medical attention is required if signs of liver dysfunction or severe allergic reactions appear.

Paracetamol Da should be avoided by individuals with known hypersensitivity to paracetamol or any excipients in the formulation, patients with severe hepatic impairment, and those who have experienced serious adverse reactions to the drug. Additionally, it should be used with caution in patients regularly consuming alcohol or taking other hepatotoxic medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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