Paracetamol + Difenhydramina Noc Hasco (Diphenhydramine Hydrochloride, Paracetamol)

Paracetamol combined with diphenhydramine acts on pain, fever and histamine‑mediated allergic pathways.

• Mild to moderate pain: provides analgesic relief for headaches, musculoskeletal discomfort and dental pain.
• Fever: lowers elevated body temperature associated with infections or inflammatory conditions.
• Allergic rhinitis or common cold symptoms: alleviates nasal congestion, sneezing, itching and watery eyes caused by histamine release.

• Paracetamol exerts central analgesic and antipyretic effects by inhibiting cyclooxygenase enzymes, which reduces prostaglandin synthesis in the brain. Diphenhydramine hydrochloride is a first‑generation H1‑receptor antagonist that blocks histamine binding at peripheral sites and crosses the blood‑brain barrier, providing antihistamine activity and sedation through anticholinergic effects.

Paracetamol + diphenhydramine may cause a range of adverse reactions.

Common Side Effects

• Drowsiness or sedation
• Dry mouth or throat
• Nausea or upset stomach
• Dizziness or light‑headedness
• Blurred vision
• Constipation or mild urinary retention

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis) with rash, swelling, or difficulty breathing
• Stevens‑Johnson syndrome or toxic epidermal necrolysis
• Hepatotoxicity, especially with overdose of paracetamol
• Cardiac arrhythmias or tachycardia
• Seizures in overdose situations
• Severe skin reactions such as drug reaction with eosinophilia and systemic symptoms (DRESS)

When using Paracetamol + diphenhydramine, consider the following precautions.

• Assess liver function: avoid in patients with severe hepatic impairment.
• Avoid alcohol: concurrent intake increases risk of liver injury.
• Use caution in the elderly: heightened susceptibility to sedation and anticholinergic effects.
• Do not exceed the recommended daily dose of paracetamol to prevent hepatotoxicity.
• Avoid concomitant CNS depressants: may enhance drowsiness and impair coordination.
• Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Paracetamol + diphenhydramine can interact with several medicines.

Major Interactions (Avoid)

• Other paracetamol‑containing products: risk of cumulative overdose and liver damage.
• Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase diphenhydramine plasma levels.
• Alcoholic beverages: potentiate hepatotoxic risk of paracetamol.

Moderate Interactions (Monitor Closely)

• Anticoagulants such as warfarin: may enhance bleeding tendency.
• Other CNS depressants (benzodiazepines, opioids, antihistamines): increased sedation and respiratory depression.
• Anticholinergic drugs (e.g., atropine, tricyclic antidepressants): additive dry‑mouth and urinary retention effects.