Paracetamol Dr.Max (Paracetamol)

Paracetamol Dr.Max is an analgesic and antipyretic that works on the central pain‑processing pathways and fever‑regulating mechanisms.

• Pain: provides relief of mild to moderate acute pain such as headache, toothache or musculoskeletal discomfort.
• Fever: lowers elevated body temperature associated with infections or inflammatory conditions.
• Headache: reduces the intensity of tension‑type or mild migraine headaches.

• Paracetamol inhibits cyclooxygenase enzymes (COX‑1 and COX‑2) within the central nervous system, leading to decreased synthesis of prostaglandins that mediate pain perception and thermoregulation. The peripheral anti‑inflammatory effect is minimal, allowing it to act primarily as an analgesic and antipyretic without significant anti‑inflammatory activity.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: mild stomach upset that may accompany dosing.
• Skin rash: transient erythema or mild itching.
• Elevated liver enzymes: mild, usually reversible changes.
• Dizziness: occasional light‑headed sensation.
• Gastrointestinal discomfort: mild abdominal pain.

Serious or Rare Side Effects

• Hepatotoxicity: severe liver injury, especially with overdose.
• Stevens‑Johnson syndrome: rare severe skin reaction.
• Anaphylaxis: immediate hypersensitivity requiring emergency care.
• Blood dyscrasias: rare cases of agranulocytosis or thrombocytopenia.
• Renal impairment: uncommon acute kidney injury in susceptible individuals.

Paracetamol should be used with awareness of specific safety considerations.

• Dosage limits: do not exceed the maximum daily amount recommended by a healthcare professional.
• Liver disease: avoid use or seek medical advice if you have existing hepatic impairment.
• Alcohol consumption: limit intake as concurrent alcohol may increase liver risk.
• Pregnancy and breastfeeding: consult a physician before use during pregnancy or lactation.
• Drug interactions: review concomitant medications for potential interactions.
• Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Paracetamol can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

• Warfarin: may enhance anticoagulant effect, increasing bleeding risk.
• Isoniazid: can potentiate hepatotoxicity when combined.

Moderate Interactions (Monitor Closely)

• Carbamazepine: may increase metabolism of paracetamol, reducing analgesic effect.
• Rifampicin: can lower plasma concentrations of paracetamol.
• Phenobarbital: may accelerate paracetamol clearance.
• Oral contraceptives: may slightly increase risk of liver enzyme elevation.
• High‑dose vitamin C: can affect renal excretion of paracetamol metabolites.