Paracetamol Farmoz (Paracetamol)

Paracetamol Farmoz is an analgesic and antipyretic that acts on the body's pain and fever pathways.

• Headache: Relieves pain associated with tension‑type and mild migraine headaches.
• Fever: Lowers elevated body temperature in febrile illnesses.
• Musculoskeletal pain: Reduces discomfort from muscle aches, back strain and minor joint inflammation.
• Dental pain: Alleviates pain following dental procedures or toothache.
• Cold‑related symptoms: Helps ease mild pain and fever that accompany common colds.

• Paracetamol inhibits the cyclo‑oxygenase enzymes in the central nervous system, particularly COX‑2, leading to reduced synthesis of prostaglandins that mediate pain and fever. This central action provides analgesic and antipyretic effects without significant anti‑inflammatory activity.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: Mild stomach upset may be reported.
• Rash: Skin redness or mild itching.
• Elevated liver enzymes: Small increases seen in routine blood tests.
• Headache: Paradoxical headache in a minority of users.

Serious or Rare Side Effects

• Severe liver injury: Possible with overdose or chronic high‑dose use.
• Stevens‑Johnson syndrome: Rare severe skin reaction.
• Anaphylaxis: Uncommon but potentially life‑threatening allergic response.
• Blood disorders: Rare cases of thrombocytopenia or neutropenia.

Paracetamol should be used with awareness of its safety profile and proper handling.

• Dose limits: Do not exceed the maximum daily amount recommended by a healthcare professional.
• Alcohol use: Limit intake, as combined use can increase liver risk.
• Pre‑existing liver disease: Use only under medical supervision.
• Concomitant medications: Review other products containing paracetamol to avoid duplication.
• Pregnancy and breastfeeding: Discuss with a healthcare provider before use.
• Store below 25°C: Keep in the original packaging, protect from moisture and direct sunlight.

Paracetamol can interact with several medicines, requiring attention to dosage and monitoring.

Major Interactions (Avoid)

• Warfarin: May enhance anticoagulant effect and increase bleeding risk.
• Isoniazid: Combined use can raise the chance of liver toxicity.

Moderate Interactions (Monitor Closely)

• Antiepileptic drugs (e.g., carbamazepine, phenytoin): May reduce paracetamol clearance.
• Rifampicin: Increases metabolism, potentially lowering efficacy.
• HIV protease inhibitors: May alter paracetamil metabolism.
• Oral contraceptives: May slightly increase hepatic enzyme activity.
• High‑dose vitamin C: Can affect renal excretion of paracetamol metabolites.