Paracetamol Hasco, 500mg Proszek Doustny (Paracetamol)

Paracetamol is an analgesic and antipyretic that acts on pain and fever pathways.

• Headache: provides relief from mild to moderate tension‑type headaches.
• Fever: reduces elevated body temperature in febrile conditions.
• Musculoskeletal pain: alleviates discomfort from strains, sprains and minor back pain.
• Dental pain: eases pain associated with toothache or dental procedures.
• Menstrual cramps: helps lessen dysmenorrhoeic pain.
• Common cold symptoms: contributes to overall symptom relief when fever or aches are present.

• Paracetamol exerts its effect primarily by inhibiting cyclooxygenase enzymes in the central nervous system, which reduces prostaglandin synthesis. This action lowers the pain‑sensing threshold and modulates the hypothalamic heat‑regulation centre, producing analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: mild stomach upset may be experienced.
• Rash: occasional skin redness or mild itching.
• Elevated liver enzymes: transient increase detected in blood tests.
• Headache: paradoxical headache may appear in some users.
• Dizziness: brief sensation of light‑headedness.

Serious or Rare Side Effects

• Severe liver injury: risk increases with overdose or chronic high‑dose use.
• Stevens‑Johnson syndrome: rare severe skin reaction.
• Blood disorders: uncommon cases of thrombocytopenia or neutropenia.
• Hypersensitivity reactions: anaphylaxis or angioedema in extremely rare cases.
• Acute kidney injury: very rare, usually linked to overdose or pre‑existing renal disease.

Paracetamol should be used according to professional guidance and with awareness of specific safety considerations.

• Dose limitation: do not exceed the maximum daily amount recommended for adults.
• Liver health: avoid use in patients with severe hepatic impairment or active liver disease.
• Alcohol consumption: limit alcohol intake while using this product to reduce liver risk.
• Pregnancy and lactation: consult a healthcare professional before use during pregnancy or while breastfeeding.
• Drug interactions: review concomitant medications for potential interactions.
• Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Paracetamol may interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

• Warfarin: may enhance anticoagulant effect and increase bleeding risk.
• Isoniazid: can potentiate hepatotoxicity when combined with paracetamol.

Moderate Interactions (Monitor Closely)

• Antiepileptic drugs (e.g., carbamazepine, phenytoin): may increase metabolism of paracetamol, lowering its effectiveness.
• Rifampicin: induces hepatic enzymes that can reduce paracetamol plasma levels.
• Oral contraceptives: may slightly increase the risk of liver enzyme elevation.
• High‑dose vitamin C: large amounts can affect paracetamol metabolism.
• Cimetidine: may alter paracetamet​e​