Paracetamol/Ibuprofen Acino (Ibuprofen, Paracetamol)

Paracetamol/Ibuprofen Acino combines two analgesic agents that act on inflammatory and temperature‑regulating pathways to relieve discomfort.

• Headache: provides rapid relief of mild to moderate headache pain.
• Musculoskeletal pain: reduces inflammation and eases pain in muscles, joints and back.
• Fever: lowers elevated body temperature in febrile conditions.
• Dental pain: alleviates pain associated with dental procedures or infections.
• Menstrual discomfort: helps lessen cramps and associated lower‑back pain.

• Paracetamol works primarily by inhibiting central cyclooxygenase enzymes, reducing prostaglandin synthesis in the brain to lower pain perception and temperature. Ibuprofen blocks cyclooxygenase‑1 and cyclooxygenase‑2 enzymes peripherally, decreasing prostaglandin production that mediates inflammation, pain and fever.

Paracetamol/Ibuprofen Acino may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

• Nausea: mild stomach upset or queasy feeling.
• Dyspepsia: occasional indigestion or heartburn.
• Headache: transient headache unrelated to the condition being treated.
• Dizziness: brief episodes of light‑headedness.
• Rash: mild skin redness or itching.

Serious or Rare Side Effects

• Hepatotoxicity: signs of liver injury such as jaundice or dark urine.
• Gastrointestinal bleeding: vomiting blood or black stools.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Renal impairment: reduced urine output or swelling.
• Anaphylaxis: sudden difficulty breathing, swelling of face or throat.

When using Paracetamol/Ibuprofen Acino, consider the following safety measures:

• Liver function: avoid use in patients with severe hepatic impairment.
• Kidney function: use cautiously in individuals with renal disease.
• Cardiovascular risk: monitor patients with hypertension or heart disease.
• Gastrointestinal health: avoid in active ulcers or a history of GI bleeding.
• Allergic reactions: discontinue if rash, itching or swelling occurs.
• Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture.

Paracetamol/Ibuprofen Acino can interact with several medicines; careful review of a patient’s medication list is essential.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• High‑dose aspirin aspirin: heightened gastrointestinal toxicity.
• Selective COX‑2 inhibitors: additive renal and cardiovascular effects.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in antihypertensive efficacy.
• Diuretics: enhanced risk of renal function decline.
• Lithium: ibuprofen may raise serum lithium levels.
• Methotrexate: ibuprofen can reduce renal clearance of methotrexate.