Product image of Paracetamol Krka (Paracetamol) supplied by GNH India

Paracetamol Krka

Active Ingredient:
Paracetamol
Origin:
EU

Paracetamol Krka (Paracetamol)

Paracetamol, the active ingredient in Paracetamol Krka, is an analgesic presented as an oral tablet for oral use. It reduces fever and alleviates mild to moderate pain in adults and children when directed by a healthcare professional.

GNH India supplies Paracetamol Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Paracetamol acts as an analgesic and antipyretic, providing relief across several common conditions.

  • Fever: Lowers elevated body temperature in both adults and children.
  • Headache: Relieves tension‑type and mild migraine‑associated pain.
  • Musculoskeletal pain: Reduces discomfort from strains, sprains and backache.
  • Cold and flu symptoms: Alleviates associated aches and fever.

How It Works

  • Paracetamol exerts its effect primarily by inhibiting the cyclooxygenase (COX) enzymes in the central nervous system, particularly COX‑2, which reduces prostaglandin synthesis. This action lowers the hypothalamic set‑point for temperature regulation and diminishes the perception of pain without significant peripheral anti‑inflammatory activity.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: Mild stomach upset reported by some users.
  • Skin rash: Minor dermatologic reactions.
  • Elevated liver enzymes: Transient changes in liver function tests.
  • Dizziness: Occasional light‑headedness.

Serious or Rare Side Effects

  • Hepatotoxicity: Severe liver injury, especially with overdose.
  • Stevens‑Johnson syndrome: Rare severe skin reaction.
  • Anaphylaxis: Immediate hypersensitivity requiring emergency care.
  • Blood disorders: Rare cases of agranulocytosis or thrombocytopenia.

Precautions & Warnings

Paracetamol should be used with awareness of specific safety considerations.

  • Assess liver function: Avoid use in patients with existing hepatic impairment.
  • Limit alcohol intake: Concomitant alcohol increases risk of liver toxicity.
  • Monitor dosage: Do not exceed the recommended total daily amount.
  • Use in pregnancy: Only under medical advice, especially in the third trimester.
  • Store below 25°C: Keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol may interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Alcohol: Heightens risk of liver damage.
  • Warfarin: May potentiate anticoagulant effect, increasing bleeding risk.
  • Isoniazid: Increases potential for hepatotoxicity.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: May reduce paracetamol plasma levels.
  • Phenobarbital: Can increase metabolism, lowering efficacy.
  • Oral contraceptives: May slightly reduce contraceptive effectiveness.

Frequently Asked Questions

Paracetamol Krka is used to relieve mild to moderate pain such as headache, muscle aches, and to reduce fever. It is commonly prescribed for conditions like colds, flu, and other febrile illnesses where antipyretic and analgesic effects are needed.

Paracetamol works by inhibiting central cyclooxygenase enzymes, especially COX‑2, which reduces the synthesis of prostaglandins in the brain. This action lowers the hypothalamic temperature set‑point and diminishes the perception of pain without providing significant anti‑inflammatory effects.

The appropriate dose of Paracetamol Krka is determined by the prescribing healthcare professional based on the patient’s age, weight, and clinical condition. Patients should follow the prescriber’s instructions and never exceed the recommended total daily amount.

Paracetamol is generally considered safe for short‑term use during pregnancy and breastfeeding when prescribed by a doctor. However, it should be used only under medical guidance, especially in the third trimester, to avoid any potential risk to the fetus or infant.

To order Paracetamol Krka, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Paracetamol Krka offers analgesic and antipyretic effects without the gastrointestinal irritation associated with non‑steroidal anti‑inflammatory drugs (NSAIDs). Unlike NSAIDs, it has minimal anti‑inflammatory activity but provides a favorable safety profile for patients who need pain relief and fever reduction without increased bleeding risk.

Paracetamol Krka should be stored below 25 °C in a dry place. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Paracetamol Krka is administered orally as a tablet. It should be swallowed whole with water, unless otherwise directed by a healthcare professional. The tablet can be taken with or without food.

The most serious risks include severe liver injury (hepatotoxicity) especially with overdose or chronic excessive use, and rare hypersensitivity reactions such as Stevens‑Johnson syndrome or anaphylaxis. Prompt medical attention is required if signs of liver dysfunction or severe allergic reactions appear.

Paracetamol Krka should be avoided by individuals with known hypersensitivity to paracetamol, severe liver disease, or those who have consumed excessive alcohol. It should also be used with caution in patients taking other hepatotoxic medications, and only under medical supervision during pregnancy or lactation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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