Product image of Paracetamol/Promethazine Hydrochloride/Dextromethorphan Hydrobromide Pinewood Laboratories Limited (Dextromethorphan Hydrobromide, Promethazine Hydrochloride, Paracetamol) supplied by GNH India

Paracetamol/Promethazine Hydrochloride/Dextromethorphan Hydrobromide Pinewood Laboratories Limited

Active Ingredient:
Dextromethorphan Hydrobromide, Promethazine Hydrochloride, Paracetamol
Origin:
EU

Paracetamol/Promethazine Hydrochloride/Dextromethorphan Hydrobromide Pinewood Laboratories Limited (Dextromethorphan Hydrobromide, Promethazine Hydrochloride, Paracetamol)

Paracetamol, the active ingredient in Paracetamol/Promethazine Hydrochloride/Dextromethorphan Hydrobromide Pinewood Laboratories Limited, is an analgesic and antipyretic presented as a tablet for oral use. It relieves mild to moderate pain and reduces fever in adults and children.

GNH India supplies Paracetamol/Promethazine Hydrochloride/Dextromethorphan Hydrobromide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pinewood Laboratories Limited

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Indications & Clinical Uses

Paracetamol/Promethazine/Dextromethorphan is a combination product that acts on several symptom pathways of upper respiratory infections and associated discomfort.

  • Common cold: alleviates fever, headache, and mild pain while reducing cough frequency.
  • Seasonal allergy: helps control sneezing and watery eyes together with pain relief.
  • Acute bronchitis: eases chest discomfort and suppresses persistent cough.

How It Works

  • Paracetamol reduces prostaglandin synthesis in the central nervous system, providing analgesic and antipyretic effects. Promethazine blocks histamine H1 receptors and exerts anticholinergic activity, producing antihistamine and anti‑emetic actions. Dextromethorphan acts as a sigma‑1 receptor agonist and NMDA‑receptor antagonist in the medullary cough centre, suppressing the cough reflex.

Side Effects

Paracetamol/Promethazine/Dextromethorphan may cause a range of adverse reactions.

Common Side Effects

  • Drowsiness: mild sedation that may affect alertness.
  • Dry mouth: reduced salivation leading to throat discomfort.
  • Nausea: mild stomach upset.
  • Dizziness: transient light‑headedness.
  • Constipation: slowed gastrointestinal motility.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Hepatotoxicity: elevated liver enzymes with excessive paracetamol exposure.
  • Cardiac arrhythmia: irregular heartbeat linked to promethazine.
  • Neuropsychiatric effects: hallucinations or confusion from dextromethorphan overdose.

Precautions & Warnings

When using this combination product, consider the following safety measures:

  • Liver function monitoring: avoid high daily doses of paracetamol.
  • Sedation risk: limit activities requiring full alertness such as driving.
  • Contraindication in children under 6: not recommended for young children due to dosing complexity.
  • Interaction with MAO inhibitors: avoid concurrent use because of dextromethorphan.
  • Pregnancy and lactation: use only if clearly needed and prescribed.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol/Promethazine/Dextromethorphan can interact with several medicines. Evaluate each combination before prescribing.

Major Interactions (Avoid)

  • MAO inhibitors: risk of serotonin syndrome with dextromethorphan.
  • Warfarin: increased bleeding risk when combined with high‑dose paracetamol.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): additive sedation.
  • Anticholinergic drugs: heightened anticholinergic burden.
  • CYP2D6 inhibitors (e.g., fluoxetine): increased dextromethorphan levels.
  • Alcohol: enhanced hepatotoxic potential of paracetamol.

Frequently Asked Questions

The product is a fixed‑dose combination that provides analgesic, antipyretic, antihistamine and cough‑suppressant effects. It is commonly used to relieve fever, headache, mild pain, nasal congestion, sneezing, and persistent cough associated with upper‑respiratory tract infections, seasonal allergies, and acute bronchitis.

Paracetamol inhibits central prostaglandin synthesis to lower pain and fever. Promethazine blocks H1 histamine receptors and has anticholinergic activity, reducing allergy symptoms and nausea. Dextromethorphan acts on sigma‑1 and NMDA receptors in the medullary cough centre, dampening the cough reflex.

Dosage is individualized by the prescribing clinician based on the patient’s age, weight, clinical condition and other medicines. The prescriber determines the appropriate strength and frequency according to local guidelines and product labeling.

Paracetamol is generally considered low‑risk in pregnancy when used at recommended doses, but promethazine and dextromethorphan cross the placenta and are classified with caution. The product should only be used in pregnancy or while breastfeeding if the potential benefit outweighs any possible risk and under medical supervision.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

The fixed‑dose formulation offers convenience by targeting several symptoms with one tablet, reducing the need for multiple separate products. Single‑ingredient agents may be preferred when only one symptom requires treatment or when a patient has contraindications to any component of the combination.

Store the tablets at ambient temperature, preferably below 25 °C, in the original container. Protect them from moisture, excessive heat and direct sunlight to maintain potency and stability.

The tablets are intended for oral administration with a glass of water. They may be taken with or without food, unless the prescribing clinician advises otherwise.

Serious risks include severe allergic reactions, hepatotoxicity from excessive paracetamol, cardiac arrhythmias linked to promethazine, and neuro‑psychiatric effects such as hallucinations from dextromethorphan overdose. Patients should seek immediate medical attention if any of these symptoms occur.

Individuals with known hypersensitivity to any component, severe liver disease, children under six years of age, patients taking MAO inhibitors, or those with certain cardiac conduction disorders should avoid this medication unless a healthcare professional determines it is safe.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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