Product image of Paracetamol Sameko (Paracetamol) supplied by GNH India

Paracetamol Sameko

Active Ingredient:
Paracetamol
Origin:
EU

Paracetamol Sameko (Paracetamol)

Paracetamol, the active ingredient in Paracetamol Sameko, is an analgesic presented as an oral formulation for systemic use. It provides pain relief and fever reduction in adults and children.

GNH India supplies Paracetamol Sameko as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sameko Farma B.V.

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Indications & Clinical Uses

Paracetamol is an analgesic‑antipyretic that acts on the central nervous system to relieve pain and reduce fever.

  • Mild to moderate pain: provides relief of headaches, musculoskeletal discomfort and dental pain.
  • Fever: lowers elevated body temperature in infections and inflammatory conditions.
  • Post‑operative discomfort: helps manage pain after minor surgical procedures.

How It Works

  • Paracetamol exerts its effect primarily by inhibiting the cyclooxygenase (COX) enzymes in the central nervous system, especially COX‑2, leading to reduced synthesis of prostaglandins that mediate pain and fever. Its action is largely peripheral‑independent, which accounts for the minimal anti‑inflammatory activity compared with non‑steroidal anti‑inflammatory drugs.

Side Effects

Paracetamol may cause adverse reactions, which are categorized by frequency.

Common Side Effects

  • Nausea: mild stomach upset that usually resolves without intervention.
  • Skin rash: occasional mild erythema or itching.
  • Elevated liver enzymes: transient increase detectable in blood tests.
  • Headache: rare occurrence of mild headache.
  • Dizziness: occasional light‑headed sensation.

Serious or Rare Side Effects

  • Severe liver injury: possible with overdose or chronic high‑dose use.
  • Allergic anaphylaxis: rare but potentially life‑threatening reaction.
  • Blood disorders: very rare cases of agranulocytosis or thrombocytopenia.

Precautions & Warnings

When using Paracetamol Sameko, consider the following precautions.

  • Dose limitation: do not exceed the recommended daily maximum to avoid hepatotoxicity.
  • Alcohol use: avoid excessive alcohol consumption while taking the product.
  • Liver disease: use only under medical supervision in patients with hepatic impairment.
  • Renal impairment: monitor kidney function in patients with reduced renal clearance.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol can interact with other medicines; interactions are grouped by clinical significance.

Major Interactions (Avoid)

  • Strong CYP2E1 inducers (e.g., rifampicin): may increase hepatotoxic risk.
  • Chronic high‑dose alcohol use: elevates risk of liver injury.
  • Concomitant use of other hepatotoxic agents: may compound liver damage.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Isoniazid: may increase liver enzyme levels, necessitating periodic liver function tests.
  • Carbamazepine: may reduce analgesic efficacy of paracetamol.

Frequently Asked Questions

Paracetamol Sameko contains the active ingredient paracetamol, which is used to relieve mild to moderate pain such as headaches, muscle aches, dental pain, and to reduce fever associated with infections or inflammatory conditions.

Paracetamol works by inhibiting central cyclooxygenase enzymes, especially COX‑2, which reduces the production of prostaglandins involved in pain signaling and temperature regulation, thereby providing analgesic and antipyretic effects.

The appropriate dose of Paracetamol Sameko is determined by a qualified prescriber based on the patient’s age, weight, clinical condition, and local regulatory guidelines. Patients should follow the healthcare professional’s instructions and not exceed the recommended maximum daily amount.

Paracetamol is generally considered compatible with pregnancy and lactation when used at recommended doses, but a healthcare professional should evaluate each case. Pregnant or nursing individuals should consult their doctor before starting treatment.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Paracetamol differs from non‑steroidal anti‑inflammatory drugs (NSAIDs) by having minimal anti‑inflammatory activity and a lower risk of gastrointestinal irritation. It is often preferred when NSAIDs are contraindicated, but it lacks the anti‑platelet effects of aspirin and does not provide the same level of inflammation control as ibuprofen or naproxen.

Paracetamol Sameko should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in damp or excessively hot environments.

Paracetamol Sameko is supplied as an oral dosage form intended for swallowing with water. The exact administration method (tablet, capsule, or liquid) should follow the prescribing information provided by the healthcare professional.

The most serious risk is hepatotoxicity, which can occur with overdose or chronic high‑dose use, potentially leading to acute liver failure. Rarely, severe allergic reactions such as anaphylaxis may develop. Patients should seek immediate medical attention if they notice signs of liver injury or allergic response.

Paracetamol Sameko should be avoided by individuals with known hypersensitivity to paracetamol or any excipients in the formulation, patients with severe liver disease unless specifically directed by a physician, and those who have exceeded the recommended daily dose of paracetamol from any source.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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