Product image of Paracetamol + Tiocolquicosido Azevedos (Paracetamol, Thiocolchicoside) supplied by GNH India

Paracetamol + Tiocolquicosido Azevedos

Active Ingredient:
Paracetamol, Thiocolchicoside
Origin:
EU

Paracetamol + Tiocolquicosido Azevedos (Paracetamol, Thiocolchicoside)

Paracetamol, the active ingredient in Paracetamol + Thiocolchicoside, is an analgesic/antipyretic presented as an oral tablet for systemic use. It relieves mild to moderate pain and reduces fever in adults and children. Thiocolchicoside, also present, acts as a skeletal muscle relaxant that helps ease muscle spasm associated with acute musculoskeletal discomfort.

GNH India supplies Paracetamol + Thiocolchicoside as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratórios Azevedos - Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

Paracetamol + Thiocolchicoside combines analgesic and muscle‑relaxant actions to address pain‑related conditions and associated muscle tension.

  • Acute musculoskeletal pain: provides pain relief while reducing muscle spasm.
  • Fever: lowers elevated body temperature in febrile states.
  • Muscle spasm: relaxes skeletal muscles to improve mobility and comfort.

How It Works

  • Paracetamol exerts its analgesic and antipyretic effects by centrally inhibiting cyclo‑oxygenase enzymes, decreasing prostaglandin synthesis in the brain, and modulating the hypothalamic heat‑regulation centre. Thiocolchicoside acts as a competitive antagonist at NMDA receptors and enhances GABA‑mediated inhibition, leading to reduced skeletal muscle tone and alleviation of spasticity.

Side Effects

Paracetamol + Thiocolchicoside may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Dizziness: transient light‑headedness.
  • Headache: occasional tension‑type headache.
  • Dry mouth: reduced salivation.
  • Drowsiness: mild sedation.
  • Gastro‑intestinal discomfort: mild abdominal pain.

Serious or Rare Side Effects

  • Allergic reactions: rash, pruritus, or angioedema.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Blood disorders: leukopenia or thrombocytopenia.
  • Seizures: rare central nervous system excitation.
  • Anaphylaxis: life‑threatening hypersensitivity.

Precautions & Warnings

When using Paracetamol + Thiocolchicoside, consider the following safety measures.

  • Liver function monitoring: avoid use in patients with severe hepatic impairment.
  • Alcohol avoidance: limit alcohol intake to reduce liver risk.
  • Age restriction: not recommended for children under 12 years without medical supervision.
  • Renal caution: adjust use in severe renal dysfunction.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol + Thiocolchicoside can interact with several medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Alcohol: increases risk of hepatotoxicity.
  • Warfarin: may enhance anticoagulant effect and bleeding.
  • Carbamazepine: induces metabolism, reducing efficacy.
  • Other hepatotoxic drugs: combined liver stress.
  • Central nervous system depressants: excessive sedation.

Moderate Interactions (Monitor Closely)

  • CYP450 substrates: possible altered plasma levels.
  • Antihistamines: may increase drowsiness.
  • Antidepressants: monitor for serotonin syndrome.
  • NSAIDs: additive gastrointestinal irritation.
  • Oral contraceptives: potential reduction in effectiveness.

Frequently Asked Questions

Paracetamol + Thiocolchicoside is a fixed‑dose oral tablet that combines an analgesic/antipyretic with a skeletal muscle relaxant. It is used to relieve mild to moderate pain, reduce fever, and ease associated muscle spasm in conditions such as acute musculoskeletal discomfort.

Paracetamol acts centrally by inhibiting cyclo‑oxygenase enzymes, which lowers prostaglandin production in the brain and resets the hypothalamic temperature set‑point. This results in analgesia and antipyresis, helping to alleviate pain and fever.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and other medications. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety in pregnancy and lactation has not been fully established. Healthcare providers should evaluate the risk‑benefit ratio before prescribing to pregnant or nursing women, and patients should discuss any concerns with their doctor.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑ingredient analgesics, the combination adds a muscle‑relaxant component, which can be advantageous when pain is accompanied by spasm. Unlike opioid analgesics, it does not carry a risk of dependence, but it lacks the potency of stronger narcotics for severe pain.

Paracetamol + Thiocolchicoside tablets should be stored at room temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the container tightly closed and out of reach of children.

The tablet is taken orally with a full glass of water. It may be taken with or without food, but patients should follow the prescriber’s guidance regarding timing relative to meals.

Serious risks include signs of liver injury such as jaundice or dark urine, severe allergic reactions like rash or swelling, and rare skin conditions such as Stevens‑Johnson syndrome. Any of these symptoms require immediate medical attention.

Patients with known hypersensitivity to paracetamol, thiocolchicoside, or any excipients should avoid the product. It is also contraindicated in individuals with severe hepatic impairment, uncontrolled hypertension, or those taking medications that strongly interact as listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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