Paracetamolo Coop (Paracetamol)

Paracetamolo Coop is an analgesic and antipyretic that acts on common pain‑related pathways and fever mechanisms.

• Headache: provides relief of mild to moderate tension‑type or migraine‑associated pain.
• Fever: reduces elevated body temperature in infectious or inflammatory states.
• Musculoskeletal pain: eases discomfort from strains, sprains and minor joint aches.
• Dental pain: alleviates pain following dental procedures or toothache.
• Menstrual cramps: helps lessen cramping discomfort associated with menstruation.

• Paracetamol reduces pain and fever by inhibiting cyclo‑oxygenase enzymes in the central nervous system, which lowers prostaglandin synthesis. This action decreases the perception of pain and resets the hypothalamic temperature set‑point, providing antipyretic effects without significant peripheral anti‑inflammatory activity.

Paracetamolo Coop may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

• Nausea: occasional mild stomach upset.
• Skin rash: transient erythema or mild itching.
• Elevated liver enzymes: mild, reversible changes in liver function tests.

Serious or Rare Side Effects

• Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.
• Toxic hepatitis: acute liver injury with jaundice and elevated transaminases.
• Anaphylaxis: rapid onset of breathing difficulty, swelling and hypotension.
• Blood dyscrasias: rare cases of agranulocytosis or thrombocytopenia.

Paracetamolo Coop should be used with attention to known safety considerations.

• Liver disease: avoid or limit use in patients with existing hepatic impairment.
• Alcohol use: limit concurrent alcohol intake to reduce hepatotoxic risk.
• Pregnancy: use only under medical supervision, especially in the third trimester.
• Age: adjust use in children according to pediatric dosing guidelines.
• Drug interactions: review concomitant medications for potential CYP450 involvement.
• Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Paracetamolo Coop can interact with several medicines, requiring awareness of the interaction level.

Major Interactions (Avoid)

• Warfarin: increased anticoagulant effect may raise bleeding risk.
• Isoniazid: combined use can heighten risk of liver toxicity.

Moderate Interactions (Monitor Closely)

• Antiepileptics (e.g., carbamazepine, phenytoin): may alter paracetamol metabolism.
• Alcohol: concurrent use can potentiate hepatotoxicity.
• Certain antibiotics (e.g., fluoroquinolones): may increase liver enzyme abnormalities.
• HIV protease inhibitors: can affect drug clearance and liver function.