Product image of Paracetamolo Galenica Senese (Paracetamol) supplied by GNH India

Paracetamolo Galenica Senese

Active Ingredient:
Paracetamol
Origin:
EU

Paracetamolo Galenica Senese (Paracetamol)

Paracetamol, the active ingredient in Paracetamolo Galenica Senese, is an analgesic/antipyretic presented as an oral tablet for oral use. It reduces fever and relieves mild to moderate pain in adults and children.

GNH India supplies Paracetamolo Galenica Senese as a licensed, GDP‑compliant international pharmaceutical supplier, sourced from the European Union, manufactured under GMP standards, and serving hospitals, pharmacies and clinics worldwide, and is available in bulk and packaged forms for diverse clinical needs, complying with EU pharmacopeial specifications and undergoing rigorous quality testing.

Manufacturer / TM Owner

Industria Farmaceutica Galenica Senese S.R.L..

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Indications & Clinical Uses

  • Paracetamol acts as an analgesic and antipyretic, providing symptom relief across several common conditions.
  • Fever: reduction of elevated body temperature in acute febrile states.
  • Headache: alleviation of tension‑type headache pain.
  • Musculoskeletal pain: relief of mild to moderate pain from strains, sprains or backache.
  • Post‑operative pain: control of pain following minor surgical procedures.
  • Cold symptoms: mitigation of discomfort associated with common cold.

How It Works

  • Paracetamol exerts its effect primarily by inhibiting the cyclooxygenase (COX) enzymes, especially COX‑2, in the central nervous system. This reduces the synthesis of prostaglandins that mediate pain and fever, while having minimal peripheral anti‑inflammatory activity. The exact peripheral mechanism remains incompletely understood, but central COX inhibition accounts for its antipyretic and analgesic properties.

Side Effects

Paracetamol may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset.
  • Rash: skin redness or itching.
  • Headache: mild tension‑type headache.

Serious or Rare Side Effects

  • Hepatotoxicity: potential liver injury, especially with overdose.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: severe skin reactions.
  • Anaphylaxis: rare severe allergic reaction.

Precautions & Warnings

When using paracetamol, several safety considerations should be observed to minimize risk.

  • Assess liver function: avoid use in patients with severe hepatic impairment.
  • Limit alcohol consumption: concurrent intake increases risk of liver injury.
  • Use lowest effective dose: reduces potential toxicity, especially in long‑term use.
  • Discontinue if hypersensitivity occurs: stop immediately if rash or swelling develops.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Store at ambient temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Paracetamol can interact with other medicines, and some combinations require avoidance while others need careful monitoring.

Major Interactions (Avoid)

  • Concomitant use with other hepatotoxic drugs (e.g., isoniazid, methotrexate) may increase liver injury risk.
  • Alcohol consumption: synergistic hepatotoxic effect.
  • Warfarin: may enhance anticoagulant effect, increasing bleeding risk.
  • Rifampicin: can reduce paracetamol plasma levels, decreasing efficacy.

Moderate Interactions (Monitor Closely)

  • Other NSAIDs (e.g., ibuprofen): may increase risk of gastrointestinal irritation.
  • Antiepileptic drugs (e.g., carbamazepine): may alter metabolism, requiring dose adjustment.
  • Oral contraceptives: may slightly increase hepatic enzyme activity, monitor liver function.

Frequently Asked Questions

Paracetamolo Galenica Senese contains paracetamol, which is employed as an analgesic and antipyretic. It is indicated for the relief of mild to moderate pain such as headache, musculoskeletal discomfort, and postoperative pain, as well as for the reduction of fever associated with acute infections.

Paracetamol works mainly by inhibiting cyclooxygenase enzymes in the central nervous system, especially COX‑2. This inhibition lowers the production of prostaglandins that sensitize pain pathways and reset the hypothalamic temperature set‑point, thereby providing analgesic and antipyretic effects.

The appropriate dose is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and any co‑existing health issues. Standard adult regimens typically range from 500 mg to 1000 mg every 4‑6 hours, not to exceed the maximum daily limit, but exact dosing must follow the prescriber’s instructions.

Paracetamol is generally considered compatible with pregnancy and lactation when used at recommended doses, but safety cannot be guaranteed for all individuals. Healthcare professionals should be consulted before use to weigh potential benefits against any risks specific to the mother and infant.

Enquiries are submitted through the product page on gnhindia.com, where the required quantity is entered. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and the necessary import documentation.

Paracetamol provides analgesic and antipyretic effects without the anti‑inflammatory activity typical of NSAIDs like ibuprofen. It is less likely to cause gastrointestinal irritation or affect platelet function, but it lacks the anti‑inflammatory benefit and may carry a higher risk of liver toxicity at excessive doses or when combined with other hepatotoxic agents.

The product should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the container tightly closed and out of reach of children.

Paracetamolo Galenica Senese is supplied as an oral tablet. The tablet should be swallowed whole with a glass of water, unless otherwise directed by a healthcare professional. It is intended for oral use only.

The most serious adverse events include hepatotoxicity, which can lead to acute liver failure especially after overdose, severe cutaneous reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and rare anaphylactic reactions. Prompt medical attention is required if any of these occur.

Individuals with known hypersensitivity to paracetamol or any excipients in the tablet should avoid it. Patients with severe liver disease, active alcoholism, or those taking other hepatotoxic medications should also refrain from use unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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