Product image of Parafusiv (Paracetamol) supplied by GNH India

Parafusiv

Active Ingredient:
Paracetamol
Origin:
EU

Parafusiv (Paracetamol)

Paracetamol, the active ingredient in Parafusiv, is an aniline presented as a 500 mg tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children. GNH India supplies Parafusiv as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Parafusiv is marketed across the EU and conforms to European pharmacopeial standards, ensuring consistent quality for healthcare providers worldwide.

Manufacturer / TM Owner

Pharma Bavaria Internacional (Pbi) Portugal Unipessoal Lda

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Indications & Clinical Uses

Parafusiv is an analgesic and antipyretic that acts on common pain‑related pathways and fever mechanisms.

  • Headache: provides relief of mild to moderate headache pain.
  • Musculoskeletal pain: reduces discomfort from strains, sprains and low‑back pain.
  • Fever: lowers elevated body temperature in febrile states.
  • Dental pain: eases pain associated with toothache or dental procedures.
  • Menstrual discomfort: helps alleviate menstrual‑related cramps and aches.

How It Works

  • Paracetamol exerts its effect primarily by inhibiting cyclooxygenase enzymes in the central nervous system, which reduces prostaglandin synthesis. This action lowers the pain‑transmission threshold and modulates the hypothalamic heat‑regulation centre, producing analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

Side Effects

Parafusiv is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild stomach upset may be experienced.
  • Rash: occasional skin redness or itching.
  • Elevated liver enzymes: transient increase detected in blood tests.

Serious or Rare Side Effects

  • Hepatotoxicity: risk of liver injury with overdose or chronic high‑dose use.
  • Stevens‑Johnson syndrome: rare severe skin reaction.
  • Anaphylaxis: extremely rare allergic response requiring immediate medical attention.
  • Blood disorders: rare cases of thrombocytopenia or neutropenia reported.

Precautions & Warnings

Parafusiv should be used with attention to individual health status and potential drug interactions.

  • Liver disease: avoid or limit use; monitor liver function.
  • Alcohol consumption: limit intake as it may increase hepatotoxic risk.
  • Pregnancy: consult a healthcare professional before use.
  • Children: dosage must be prescribed based on weight and age.
  • Renal impairment: use with caution and under medical guidance.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Parafusiv may interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Warfarin: may enhance anticoagulant effect, increasing bleeding risk.
  • Isoniazid: combined use can raise risk of liver toxicity.

Moderate Interactions (Monitor Closely)

  • Antiepileptics (e.g., carbamazepine, phenytoin): may reduce analgesic effect.
  • Oral contraceptives: may slightly decrease plasma concentration of paracetamol.
  • Rifampicin: may increase metabolic clearance, lowering therapeutic levels.
  • Lithium: concurrent use can affect lithium serum concentrations.
  • CYP450 inducers: substances that induce CYP enzymes may reduce drug exposure.

Frequently Asked Questions

Parafusiv contains paracetamol, an analgesic and antipyretic used to relieve mild to moderate pain such as headache, musculoskeletal discomfort, dental pain and menstrual cramps, and to lower fever in both adults and children when prescribed by a healthcare professional.

Paracetamol works by inhibiting central cyclooxygenase enzymes, which reduces the synthesis of prostaglandins involved in pain signalling and temperature regulation. This central action provides relief from pain and helps normalize body temperature without significant peripheral anti‑inflammatory effects.

The appropriate dose of Parafusiv is determined by the prescribing clinician based on the patient’s age, weight, clinical condition and local guidelines. Healthcare providers set the exact amount and frequency to ensure safe and effective therapy.

Parafusiv may be used during pregnancy or lactation only when clearly indicated and prescribed by a qualified healthcare professional. The prescriber will weigh potential benefits against any risks to the mother and fetus or infant before recommending use.

To order Parafusiv, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Parafusiv (paracetamol) offers analgesic and antipyretic effects with a lower risk of gastrointestinal irritation compared with non‑steroidal anti‑inflammatory drugs (NSAIDs). It does not provide anti‑inflammatory action, and its safety profile differs, particularly regarding renal and cardiovascular considerations.

Parafusiv tablets should be stored below 25 °C in their original packaging, protected from moisture and direct sunlight. Ensure the container is tightly closed to maintain tablet integrity throughout its shelf life.

Parafusiv is supplied as oral tablets that are swallowed whole with water. It is intended for oral use only; tablets should not be crushed, chewed or dissolved unless specifically directed by a healthcare professional.

The most serious risk of Parafusiv is hepatotoxicity, especially with overdose or chronic high‑dose use. Rare but severe reactions such as Stevens‑Johnson syndrome, anaphylaxis and blood‑disorder events have also been reported and require immediate medical attention.

Parafusiv should be avoided by individuals with known hypersensitivity to paracetamol or any tablet excipients, patients with severe liver impairment, and anyone who has experienced serious adverse reactions to paracetamol in the past. Consultation with a healthcare professional is essential before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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