Product image of Paralen Extra Proti Bolesti (Paracetamol, Caffeine) supplied by GNH India

Paralen Extra Proti Bolesti

Active Ingredient:
Paracetamol, Caffeine
Origin:
EU

Paralen Extra Proti Bolesti (Paracetamol, Caffeine)

Paracetamol, the active ingredient in Paralen Extra Proti Bolesti, is an analgesic/antipyretic presented as a tablet for oral use. It relieves mild to moderate pain and reduces fever in adults and children.

GNH India supplies Paralen Extra Proti Bolesti as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Opella Healthcare Czech S.R.O

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Indications & Clinical Uses

Paralen Extra Proti Bolesti combines paracetamol and caffeine and is used for pain and fever pathways in the body.

  • Headache: Provides relief from tension‑type and migraine‑associated headache pain.
  • Fever: Lowers elevated body temperature in febrile episodes.
  • Musculoskeletal pain: Alleviates discomfort from muscle aches, back strain and minor joint pain.

How It Works

  • Paracetamol acts centrally by inhibiting cyclooxygenase enzymes, primarily COX‑2, which reduces prostaglandin synthesis in the brain and spinal cord, leading to lowered pain perception and temperature regulation. Caffeine blocks adenosine receptors, enhancing alertness and modestly increasing analgesic potency of paracetamol.

Side Effects

Paralen Extra Proti Bolesti may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild stomach upset that may occur after dosing.
  • Headache: occasional rebound headache unrelated to the condition being treated.
  • Insomnia: difficulty falling or staying asleep, linked to caffeine content.
  • Gastro‑intestinal discomfort: mild abdominal pain or dyspepsia.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Liver injury: signs include jaundice, dark urine, or upper‑right abdominal pain.
  • Blood disorders: unexplained bruising or bleeding.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Paralen Extra Proti Bolesti should be used with caution in specific situations.

  • Liver disease: avoid or limit use, as paracetamol is metabolised by the liver.
  • Alcohol consumption: concurrent heavy drinking increases risk of hepatotoxicity.
  • Pregnancy: consult a healthcare professional before use, especially in the first trimester.
  • Breastfeeding: discuss safety with a clinician as caffeine may affect the infant.
  • Children under 12: dosage must be determined by a qualified practitioner.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Paralen Extra Proti Bolesti can interact with several medicines, requiring awareness of the interaction level.

Major Interactions (Avoid)

  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • Carbamazepine: accelerates paracetamol metabolism, reducing efficacy.
  • Isoniazid: heightens risk of liver toxicity.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs, SNRIs): may modestly raise serotonin levels.
  • Diuretics (furosemide): can enhance renal clearance of caffeine.
  • Oral contraceptives: may increase plasma concentration of paracetamol.

Frequently Asked Questions

Paralen Extra Proti Bolesti is a combination of paracetamol and caffeine indicated for the temporary relief of mild to moderate pain such as headache, fever and musculoskeletal discomfort. It is intended for short‑term use in adults and, when prescribed, in children.

Paracetamol reduces pain and fever by inhibiting central cyclooxygenase enzymes, which lowers prostaglandin production in the brain and spinal cord. The added caffeine blocks adenosine receptors, which can increase alertness and modestly boost the analgesic effect of paracetamol.

The appropriate dose is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition and local guidelines. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Paracetamol is generally considered safe in pregnancy when used at recommended doses, but caffeine exposure should be limited. Breastfeeding mothers should consult a healthcare provider, as caffeine can pass into breast milk and may affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with plain paracetamol, the addition of caffeine can enhance pain relief and reduce fatigue, making it useful for headache and fatigue‑related pain. It differs from NSAIDs, which have anti‑inflammatory activity but carry higher gastrointestinal and cardiovascular risk.

Store the tablets below 25°C in a dry place, protected from moisture and direct sunlight. Keep them in the original container to maintain stability and prevent accidental ingestion.

The product is supplied as oral tablets that should be swallowed whole with water. It is intended for systemic absorption through the gastrointestinal tract; crushing or dissolving the tablet is not recommended unless directed by a healthcare professional.

Serious risks include allergic reactions such as rash or swelling, liver injury manifested by jaundice or abdominal pain, and rare severe skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if any of these symptoms appear.

Individuals with known hypersensitivity to paracetamol, caffeine or any excipients, patients with severe liver impairment, and those taking medications that strongly interact (e.g., warfarin) should avoid this product unless a physician advises otherwise.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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