Product image of Paralgin Major (Codeine Phosphate Sesquihydrate, Paracetamol) supplied by GNH India

Paralgin Major

Active Ingredient:
Codeine Phosphate Sesquihydrate, Paracetamol
Origin:
EU

Paralgin Major (Codeine Phosphate Sesquihydrate, Paracetamol)

Codeine Phosphate Sesquihydrate, the active ingredient in Paralgin Major, is an opioid analgesic presented as a combination product with paracetamol for rectal use. It is employed to manage moderate pain and fever in adults when oral administration is unsuitable.
GNH India supplies Paralgin Major as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Karo Pharma As

1
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Indications & Clinical Uses

Paralgin Major combines a weak opioid with a non‑opioid analgesic, acting on pain pathways to relieve discomfort and reduce fever.

  • Mild to moderate acute pain: provides analgesia when oral tablets are not feasible.
  • Post‑operative pain: helps control pain after surgical procedures.
  • Fever associated with infection: lowers elevated body temperature.

How It Works

  • Codeine is converted in the liver to morphine, which binds to µ‑opioid receptors in the central nervous system, diminishing pain signal transmission. Paracetamol acts centrally to inhibit prostaglandin synthesis, reducing fever and enhancing analgesic effect, resulting in synergistic pain relief.

Side Effects

Paralgin Major may cause a range of adverse reactions, most of which are dose‑dependent and reversible.

Common Side Effects

  • Nausea
  • Dizziness
  • Constipation
  • Light‑headedness
  • Sweating

Serious or Rare Side Effects

  • Respiratory depression
  • Severe allergic reaction (anaphylaxis)
  • Hepatotoxicity due to paracetamol overload
  • Seizure
  • Low low low low low low low low low low …

Precautions & Warnings

  • When ​  ​  ​    ​  …  
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Avoid Interactions

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Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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