Product image of Paralief Cold & Flu (Phenylephrine Hydrochloride, Paracetamol, Caffeine) supplied by GNH India

Paralief Cold & Flu

Active Ingredient:
Phenylephrine Hydrochloride, Paracetamol, Caffeine
Origin:
EU

Paralief Cold & Flu (Phenylephrine Hydrochloride, Paracetamol, Caffeine)

Phenylephrine Hydrochloride, the active ingredient in Paralief Cold & Flu, is a nasal decongestant presented as a combination tablet for oral use. It treats symptoms of cold and flu, such as nasal congestion, headache, and fever, in adults and children when appropriate.

GNH India supplies Paralief Cold & Flu as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Clonmel Healthcare Ltd.

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Indications & Clinical Uses

Paralief Cold & Flu combines three active ingredients that work together to relieve a range of upper‑respiratory symptoms associated with colds and influenza:

  • Nasal congestion: Reduces swelling of nasal passages to improve airflow.
  • Headache and fever: Alleviates pain and lowers temperature.
  • General malaise: Improves overall comfort during a cold or flu episode.
  • Fatigue related to flu: Provides a mild stimulant effect to reduce drowsiness.
  • Sinus pressure: Helps relieve sinus discomfort.

How It Works

  • Paralief Cold & Flu provides a multi‑component action: phenyl‑erephrine stimulates α‑adrenergic receptors in nasal mucosa causing vasoconstriction and reduced swelling; paracetamol inhibits cyclo‑oxygenase enzymes, lowering prostaglandin synthesis to reduce pain and fever; caffeine acts centrally to counteract sedation and modestly enhances analgesic effect through adenosine‑receptor antagonism.

Side Effects

Paralief Cold & Flu may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nervousness or restlessness
  • Insomnia
  • Upset stomach or nausea
  • Mild headache
  • Increased heart rate
  • Dizziness

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • High blood pressure spikes
  • Irregular heart rhythm
  • Liver enzyme abnormalities
  • Severe skin rash or Stevens‑Johnson syndrome

Precautions & Warnings

Paralief Cold & Flu should be used with caution in specific situations and according to professional guidance.

  • Pregnancy: Consult the prescriber for risk‑benefit assessment.
  • Breastfeeding: Use only if clearly needed and prescribed.
  • Cardiovascular disease: Monitor blood pressure and heart rate.
  • Diabetes or thyroid disorders: Observe for altered glucose or metabolic response.
  • Concomitant use of other stimulants or decongestants: Avoid exceeding recommended total dose.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

  • Paralief Cold & Flu can interact with several medicines, requiring careful management.
  • Major Interactions (​A ​ ​  ) :
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  • Moderate Interaction (  ");
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Frequently Asked Questions

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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