Paramed (Ibuprofen)

Ibuprofen acts on inflammatory pathways to provide analgesic and antipyretic effects.

• Mild to moderate pain: alleviates headache, dental pain, musculoskeletal discomfort, and menstrual cramps.
• Fever: lowers elevated body temperature associated with infections or inflammatory conditions.
• Inflammatory disorders: reduces swelling and pain in conditions such as osteoarthritis and rheumatoid arthritis.

• Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate pain, fever and inflammation. This reversible inhibition limits inflammatory signaling while preserving platelet function at therapeutic doses.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia, or mild abdominal pain.
• Headache: transient headache episodes.
• Dizziness: light‑headed feeling or vertigo.
• Skin reactions: mild rash or itching.
• Elevated blood pressure: modest increase in systolic/diastolic readings.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration.
• Severe skin reactions such as Stevens‑Johnson syndrome.
• Renal impairment or acute kidney injury.
• Anaphylaxis: rapid onset of hives, swelling, and airway compromise.
• Hepatotoxicity: elevated liver enzymes or hepatitis.

When using Paramed, consider the following safety measures:

• Assess renal function: evaluate baseline kidney health before initiating therapy.
• Monitor gastrointestinal risk: avoid use in patients with a history of ulcers or bleeding.
• Evaluate cardiovascular status: use cautiously in individuals with hypertension or heart disease.
• Review concomitant medications: check for other NSAIDs or anticoagulants that may increase bleeding risk.
• Pregnancy and lactation: limit use to the shortest duration necessary and only under medical supervision.
• Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Ibuprofen may interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• High‑dose aspirin: additive gastrointestinal toxicity.
• Selective COX‑2 inhibitors (e.g., celecoxib): heightened cardiovascular risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.
• Diuretics (e.g., furosemide): may worsen kidney function.
• Lithium: increased serum lithium levels.
• Methotrexate: reduced renal clearance leading to toxicity.