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Phenylephrine Hydrochloride (Phenylephrine Hydrochloride)

Trade Name : Phenylephrine hydrochloride

Medical Purchasing Solutions, LLC

INJECTION

Strength 10 mg/mL

PHENYLEPHRINE HYDROCHLORIDE alpha-1 Adrenergic Agonist [EPC],Adrenergic alpha1-Agonists [MoA]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Phenylephrine Hydrochloride (Phenylephrine Hydrochloride) which is also known as Phenylephrine hydrochloride and Manufactured by Medical Purchasing Solutions, LLC. It is available in strength of 10 mg/mL per ml. Read more

Phenylephrine Hydrochloride (Phenylephrine Hydrochloride) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • Phenylephrine hydrochloride injection, 10 mg/mL is an alpha-1 adrenergic receptor agonist indicated for the treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia.
  • Phenylephrine hydrochloride injection is an alpha-1 adrenergic receptor agonist indicated for the treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia. (n n n )n nn
  • Phenylephrine hydrochloride injection, 10 mg/mL, is injected intravenously either as a bolus or in a dilute solution as a continuous infusion.
  • Dilute before administration. (n n n )n nn
  • u00a0
  • Dosing for treatment of hypotension during anesthesia
  • The dose should be adjusted according to the pressor response (i.e. titrate to effect). (n n n )n nn
  • Bolus intravenous injection: 40 mcg to 100 mcg every 1 to 2 minutes as needed, not to exceed 200 mcg. (n n n )n n n
  • Intravenous infusion: 10 mcg/min to 35 mcg/min, titrating to effect, not to exceed 200 mcg/min. (n n n )n n n
  • Phenylephrine hydrochloride injection, USP is a sterile, clear, colorless solution and supplied in 1 mL single-dose glass vials. Each mL contains phenylephrine hydrochloride USP, n n n .n nn
  • Injection. (n n n )n n n
  • 1 mL single-dose vials containing 10 mg phenylephrine hydrochloride (10 mg/mL). (n n n )n n n
  • None
  • None. (n n n )n nn
  • No data
  • Extravasation during intravenous administration may cause necrosis or sloughing of tissue.
  • Severe bradycardia and decreased cardiac output.
  • Allergic-type reactions
  • Concomitant use with oxytocic drugs:
  • Adverse reactions to phenylephrine hydrochloride are primarily attributable to excessive pharmacologic activity. Adverse reactions reported in published clinical studies, observational trials, and case reports of phenylephrine hydrochloride are listed below by body system. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure.
  • Cardiac disorders:
  • Gastrointestinal disorders:
  • Nervous system disorders:
  • Vascular disorders:
  • Respiratory, Thoracic and Mediastinal Disorders:
  • Skin and subcutaneous tissue disorders:
  • Most common adverse reactions during treatment: nausea, vomiting, and headache. (n n n )n nn
  • No data
  • Agonistic effects with monoamine oxidase inhibitors (MAOI), oxytocin and oxytocic drugs, tricyclic antidepressants, angiotensin and aldosterone, atropine, steroids, norepinephrine transporter inhibitors, ergot alkaloids. (n n n )n n n
  • Antagonistic effects with u03b1-adrenergic antagonists, phosphodiesterase Type 5 inhibitors, mixed u03b1- and u03b2-receptor antagonists, calcium channel blockers, benzodiazepines and ACE inhibitors, centrally acting sympatholytic agents. (n n n )n n n
  • No data
  • Pregnancy: Based on animal data, may cause fetal harm. (n n n )n n n
  • Overdose of phenylephrine hydrochloride can cause a rapid rise in blood pressure. Symptoms of overdose include headache, vomiting, hypertension, reflex bradycardia, a sensation of fullness in the head, tingling of the extremities, and cardiac arrhythmias including ventricular extrasystoles and ventricular tachycardia.
  • Phenylephrine is an alpha-1 adrenergic receptor agonist. Phenylephrine hydrochloride injection USP, 10 mg/mL is a sterile, nonpyrogenic solution for intravenous use. It must be diluted before administration as an intravenous bolus or continuous intravenous infusion. The chemical name of phenylephrine hydrochloride is (-)-n n n -hydroxy-u03b1-[(methylamino)methyl]benzyl alcohol hydrochloride, and its structural formula is depicted below:n nn
  • Phenylephrine hydrochloride, USP is a white or practically white crystals with a molecular formula of Cn n n Hn n n NOn n n u2022 HCl and a molecular weight of 203.67. It is freely soluble in water and in alcohol. n nn
  • Phenylephrine hydrochloride injection USP, 10 mg/mL is sensitive to light.
  • Each mL contains: phenylephrine hydrochloride, USP 10 mg, sodium chloride 3.5 mg, trisodium citrate dihydrate 4 mg, citric acid monohydrate 1 mg, and sodium metabisulfite u00a0u00a0u00a0u00a0u00a0u00a02 mg in water for injection. The pH is adjusted with sodium hydroxide and/or hydrochloric acid if necessary. The pH range is 3.5 to 5.5.
  • No data
  • Carcinogenesis:
  • Mutagenesis:
  • in vitro
  • S.typhimurium
  • in vitro
  • in vitro
  • in vivo
  • in vitro
  • Impairment of Fertility:
  • The evidence for the efficacy of phenylephrine hydrochloride is derived from studies of phenylephrine hydrochloride in the published literature. The literature support includes 16 studies evaluating the use of intravenous phenylephrine to treat hypotension during anesthesia. The 16 studies include 9 studies where phenylephrine was used in low-risk (ASA 1 and 2) pregnant women undergoing neuraxial anesthesia during Cesarean delivery, 6 studies in non-obstetric surgery under general anesthesia, and 1 study in non-obstetric surgery under combined general and neuraxial anesthesia. Phenylephrine has been shown to raise systolic and mean blood pressure when administered either as a bolus dose or by continuous infusion following the development of hypotension during anesthesia.
  • Phenylephrine Hydrochloride Injection, USP is a sterile, clear, colorless solution and supplied in 1 mL single-dose glass vials. Each mL contains phenylephrine hydrochloride USP, n n n .n nn
  • 10 mg/mL (1 mL)
  • 1 mL Singlen n n dose Vial:u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0 u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0 NDC 70121-1577-1n nn
  • 25 Vials in a Carton:u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0 u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0 NDC 70121-1577-5
  • Store phenylephrine hydrochloride injection USP, 10 mg/mL at 20u00b0 to 25u00b0C (68u00b0 to 77u00b0F); excursions permitted between 15u00b0 to 30u00b0C (59u00b0 to 86u00b0F) [see USP Controlled Room Temperature].
  • Protect from light. Store in carton until time of use. Vial stoppers are not manufactured with natural rubber latex.
  • The diluted solution should not be held for more than 4 hours at room temperature or for more than 24 hours under refrigerated conditions. Discard any unused portion.
  • If applicable, inform patients, family member, or caregiver that certain medical conditions and medications might influence how phenylephrine hydrochloride injection works.
  • Manufactured by:
  • Amneal Pharmaceuticals Pvt. Ltd.
  • Parenteral Unit
  • Ahmedabad 382213, INDIA
  • Distributed by:
  • Amneal Biosciences LLC
  • Bridgewater, NJ 08807
  • Rev. 04-2018-00
  • Name: Phenylephrine Hydrochloride Injection, USP
  • Strength: n n
  • Rx Only
  • Vial Label
  • Arrayn- Array
  • NDC 71872-7159-1
  • RX ONLY
  • Phenylephrine Hydrochloride Injection, USP
  • 1 - 10 mg/mL 1 mL Single Dose Vial
  • For Intravenous Use.
  • Must be diluted.
  • Protect from light.

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