Product image of Konakion Pediátrico (Phytomenadione) supplied by GNH India

Konakion Pediátrico

Active Ingredient:
Phytomenadione
Origin:
EU

Konakion Pediátrico (Phytomenadione)

Phytomenadione, the active ingredient in Konakion Pediátrico, is a vitamin K presented as a pediatric formulation for intramuscular, intravenous, and oral use. It is employed to correct vitamin K deficiency and to prevent hemorrhagic disease in newborns, as well as to reverse anticoagulant effects.

GNH India supplies Konakion Pediátrico as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cheplapharm Arzneimittel Gmbh

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Indications & Clinical Uses

Konakion Pediátrico (phytomenadione) is used in conditions affecting the vitamin K‑dependent clotting pathway.

  • Vitamin K deficiency: restores normal clotting factor activity in patients with insufficient vitamin K.
  • Hemorrhagic disease of the newborn: prevents bleeding in newborns at risk due to low vitamin K stores.
  • Anticoagulant reversal: counteracts the effects of warfarin or other vitamin K antagonists to re‑establish hemostasis.

How It Works

  • Phytomenadione acts as a cofactor for the gamma‑carboxylation of glutamate residues on clotting factors II, VII, IX and X in the liver. This enzymatic modification enables the factors to bind calcium ions, a prerequisite for the assembly of the clotting cascade and formation of a stable fibrin clot.

Side Effects

Common Side Effects

  • Injection site pain or erythema.
  • Mild fever or chills.
  • Nausea or vomiting.
  • Headache.
  • Transient elevation of liver enzymes.
  • Diarrhea.

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction.
  • Acute hemolysis.
  • Thrombosis or disseminated intravascular coagulation.
  • Severe hypotension.
  • Persistent bleeding despite therapy.
  • Serum sickness-like reaction.

Precautions & Warnings

Before administration, assess baseline vitamin K status and coagulation parameters.

  • Use with caution in patients with liver disease or impaired synthesis of clotting factors.
  • Avoid in individuals with known hypersensitivity to phytomenadione or any excipients.
  • Monitor neonates closely for signs of hyperbilirubinemia after dosing.
  • Do not co‑administer with other vitamin K preparations without medical supervision.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Major Interactions (Avoid)

  • Concurrent use with coumarin anticoagulants (e.g., warfarin) without monitoring may cause abrupt reversal of anticoagulation.
  • Simultaneous administration of other vitamin K products can diminish intended therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Broad‑spectrum antibiotics may alter gut flora and affect endogenous vitamin K levels.
  • Bile‑acid sequestrants can reduce oral absorption of phytomenadione.
  • Barbiturates and other enzyme‑inducing drugs may increase vitamin K metabolism.
  • High‑dose vitamin E may interfere with vitamin K activity.
  • Oral contraceptives may modestly affect clotting factor synthesis.

Frequently Asked Questions

Konakion Pediátrico contains phytomenadione, a form of vitamin K, and is used to treat vitamin K deficiency, prevent hemorrhagic disease in newborns, and reverse the anticoagulant effects of drugs such as warfarin by restoring functional clotting factors.

Phytomenadione serves as a cofactor for the gamma‑carboxylation of specific clotting factors (II, VII, IX, X). This modification enables the factors to bind calcium, which is essential for the assembly of the clotting cascade and the formation of a stable fibrin clot.

The dose of Konakion Pediátrico is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and the route of administration. Only a qualified healthcare professional should set the appropriate regimen.

Safety data for phytomenadione in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Konakion Pediátrico is a pediatric‑focused formulation of phytomenadione, offering flexibility for intramuscular, intravenous, or oral administration. Compared with other vitamin K preparations, it is specifically licensed for use in newborns and children, and its dosing can be tailored to pediatric needs.

The product should be stored at 2‑8 °C, protected from light, and kept in its original packaging. It must not be frozen or shaken vigorously. If the product reaches room temperature, it should be used promptly and not re‑refrigerated.

Konakion Pediátrico can be given by intramuscular injection, intravenous infusion, or oral administration, depending on the clinical indication and patient age. The route and technique should follow the prescribing clinician’s instructions and standard aseptic practices.

Serious risks include severe allergic reactions such as anaphylaxis, acute hemolysis, thrombosis or disseminated intravascular coagulation, and persistent bleeding despite treatment. Immediate medical attention is required if any of these events occur.

Patients with known hypersensitivity to phytomenadione or any excipients in the formulation should avoid its use. It is also contraindicated in individuals where abrupt reversal of anticoagulation is not medically indicated without proper supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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