Product image of Pluvicto (Lutetium (177Lu) vipivotide tetraxetan) 1,000 Injection supplied by GNH India

Pluvicto

Active Ingredient:
Lutetium (177Lu) vipivotide tetraxetan
Form:
Injection

Pluvicto (Lutetium (177Lu) vipivotide tetraxetan Injection) 1,000

Pluvicto is a prescription radioligand therapeutic agent containing the active ingredient lutetium (177Lu) vipivotide tetraxetan. Administered as an intravenous injection, it is designed to target and deliver therapeutic radiation directly to specific cancer cells. As an antineoplastic radiopharmaceutical, it works by binding to prostate-specific membrane antigen (PSMA) proteins expressed on the surface of certain prostate cancer cells.

Strength

1,000

1
Pack/s
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Indications & Clinical Uses

  • Pluvicto is indicated for the treatment of adult patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC). It is typically prescribed for patients who have already received other treatments, such as androgen receptor pathway inhibition and taxane-based chemotherapy.

Side Effects

  • Common side effects associated with Pluvicto include fatigue, dry mouth (xerostomia), nausea, anemia, decreased appetite, and constipation. It can also cause laboratory abnormalities such as decreased blood cell counts, including lymphopenia, thrombocytopenia, and leukopenia. Patients should report any persistent or severe symptoms to their healthcare provider.

Precautions & Warnings

  • Before receiving Pluvicto, patients should inform their healthcare team of any pre-existing kidney problems, bone marrow suppression, or other medical conditions. Because Pluvicto is a radioactive substance, patients must follow specific safety precautions post-treatment to minimize radiation exposure to household members and the general public. It is not indicated for use in females, and its potential effects on male fertility should be discussed with a doctor.

Avoid Interactions

  • Formal drug interaction studies have not been extensively conducted for lutetium (177Lu) vipivotide tetraxetan. However, concurrent use of other myelosuppressive agents or drugs that affect renal function may increase the risk of toxicity. Patients should provide a complete list of all medications, supplements, and herbal products they are taking to their oncology team.

Frequently Asked Questions

Pluvicto is used to treat adult patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC) who have previously undergone other treatments like androgen receptor pathway inhibition and taxane-based chemotherapy.

Pluvicto is administered as an intravenous injection by qualified healthcare professionals in specialized clinical settings equipped to handle radiopharmaceuticals.

Pluvicto is a radioligand therapeutic agent that targets and binds to PSMA-expressing cancer cells. Once bound, it delivers beta-minus radiation directly to the cells, causing DNA damage and cell death.

The most common side effects include fatigue, dry mouth, nausea, anemia, decreased appetite, and changes in bowel habits such as constipation.

Patients receiving Pluvicto must follow specific post-treatment instructions provided by their medical team, which typically include limiting close contact with others, especially children and pregnant individuals, for a designated period to reduce radiation exposure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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