Product image of Lactated Ringer's Βιοσερ (Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate, Sodium Lactate) supplied by GNH India

Lactated Ringer's Βιοσερ

Active Ingredient:
Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate, Sodium Lactate
Origin:
EU

Lactated Ringer's Βιοσερ (Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate, Sodium Lactate)

Sodium lactate, the active ingredient in Lactated Ringer's Βιοσερ, is an IV electrolyte solution presented as an injection solution for intravenous use. It helps restore intravascular volume and correct electrolyte imbalances in patients requiring fluid therapy. The formulation also includes potassium chloride, sodium chloride, and calcium chloride dihydrate, delivering a balanced electrolyte composition.

GNH India supplies Lactated Ringer's Βιοσερ as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company provides reliable global distribution, quality‑assured batches, and regulatory support for healthcare institutions.

Manufacturer / TM Owner

Vioser S.A.

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Indications & Clinical Uses

Lactated Ringer's solution is used in clinical situations that require rapid intravascular volume expansion and electrolyte replacement.

  • Fluid resuscitation: restores circulating blood volume in patients with hypovolemia due to trauma, surgery or sepsis.
  • Electrolyte replacement: supplies sodium, potassium, calcium and chloride to correct deficits in dehydrated or critically ill patients.
  • Perioperative fluid management: maintains hemodynamic stability and electrolyte balance during and after surgical procedures.
  • Treatment of dehydration: rehydrates patients with fluid loss from gastrointestinal disorders, burns or excessive sweating.

How It Works

  • Upon intravenous infusion, Lactated Ringer's solution delivers sodium, potassium, calcium, chloride and lactate ions in concentrations that approximate extracellular fluid. Lactate is metabolized by the liver to bicarbonate, helping to buffer metabolic acidosis. The balanced electrolyte profile expands plasma volume, improves tissue perfusion, and supports normal cellular function while minimizing shifts in acid‑base balance.

Side Effects

Adverse reactions to Lactated Ringer's solution may vary in frequency and severity.

Common Side Effects

  • Injection site pain or erythema
  • Mild hyperkalemia
  • Transient hypotension
  • Nausea or vomiting

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction
  • Significant hypernatremia or hyperkalemia leading to cardiac arrhythmia
  • Fluid overload with pulmonary edema

Precautions & Warnings

When using Lactated Ringer's solution, clinicians should consider several precautionary measures to ensure patient safety.

  • Renal impairment: monitor serum electrolytes and fluid balance closely.
  • Cardiac disease: avoid rapid infusion in patients prone to arrhythmias.
  • Pregnancy: use only if the expected benefit justifies potential risk to the fetus.
  • Concomitant IV fluids: assess total fluid volume to prevent overload.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lactated Ringer's solution can interact with other medications or solutions, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Hyperkalemic agents (e.g., potassium supplements): may cause dangerous potassium elevation.
  • Calcium‑containing infusions: risk of calcium overload and precipitation.
  • Alkalinizing agents (e.g., sodium bicarbonate): may exacerbate metabolic alkalosis.

Moderate Interactions (Monitor Closely)

  • Loop or thiazide diuretics: alter electrolyte balance, requiring monitoring.
  • ACE inhibitors or ARBs: can increase serum potassium levels.
  • Blood transfusions with citrate: may affect calcium levels.

Frequently Asked Questions

Lactated Ringer's Βιοσερ is an intravenous electrolyte solution employed to restore intravascular volume, replace lost electrolytes, and maintain fluid balance. It is commonly used in fluid resuscitation for hypovolemic patients, peri‑operative management to support hemodynamics, and treatment of dehydration caused by illness, burns, or excessive fluid loss.

Sodium lactate acts as a metabolizable anion that the liver converts to bicarbonate, helping to correct metabolic acidosis. Together with sodium, potassium, calcium, and chloride, it provides a balanced electrolyte composition that expands plasma volume, improves tissue perfusion, and supports normal cellular function without causing large shifts in acid‑base status.

The dose of Lactated Ringer's Βιοσερ is individualized by the prescribing clinician based on the patient’s weight, clinical condition, and fluid requirements. Typical regimens involve bolus or continuous infusion rates calculated to achieve target intravascular volume and electrolyte goals, with adjustments made according to ongoing monitoring.

Safety data for Lactated Ringer's Βιοσερ in pregnancy and lactation are limited. The solution may be used when the expected maternal benefit outweighs potential fetal risk, and it is generally considered compatible with breastfeeding because only small amounts of electrolytes are transferred. Clinicians should evaluate each case carefully.

To order Lactated Ringer's Βιοσερ, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Lactated Ringer's contains a balanced mix of electrolytes and lactate, whereas normal saline is a simple 0.9% sodium chloride solution. The lactate in LR is metabolized to bicarbonate, helping to buffer acidosis, while normal saline can cause hyperchloremic metabolic acidosis with large volumes. LR is often preferred for peri‑operative and trauma resuscitation when a more physiologic electrolyte profile is desired.

Lactated Ringer's Βιοσερ should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution vigorously. Before administration, allow the product to reach room temperature if required, and inspect for particulate matter or discoloration.

The solution is administered intravenously, either as a rapid bolus or a controlled infusion, depending on the clinical scenario. Infusion sets with appropriate flow‑rate regulators are used, and the administration site should be monitored for signs of infiltration, phlebitis, or adverse reactions throughout the infusion.

Serious risks associated with Lactated Ringer's include severe allergic reactions such as anaphylaxis, significant electrolyte disturbances (e.g., hyperkalemia or hypernatremia) that can precipitate cardiac arrhythmias, and fluid overload leading to pulmonary edema. Prompt recognition and management of these events are essential.

Lactated Ringer's is contraindicated in patients with known hypersensitivity to any component of the solution. Caution is advised for individuals with severe renal failure, uncontrolled hyperkalemia, or conditions predisposing to fluid overload, such as congestive heart failure or severe pulmonary edema, where alternative fluid therapy may be required.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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