Product image of Lactated Ringer’s Injection Fresenius (Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate, Sodium Lactate) supplied by GNH India

Lactated Ringer’s Injection Fresenius

Active Ingredient:
Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate, Sodium Lactate
Origin:
EU

Lactated Ringer’s Injection Fresenius (Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate, Sodium Lactate)

Lactated Ringer's solution, the active ingredient in Lactated Ringer’s Injection Fresenius, is an electrolyte solution presented as an injection solution for intravenous use. It is used to restore extracellular fluid volume and replace electrolytes in patients requiring fluid resuscitation, peri‑operative hydration, or electrolyte replacement.

GNH India supplies Lactated Ringer’s Injection Fresenius as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Hellas Single Member S.A.

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Indications & Clinical Uses

Lactated Ringer’s solution is employed in clinical situations that demand rapid restoration of fluid and electrolyte balance.

  • Fluid resuscitation: repletes intravascular volume in hypovolemic patients.
  • Electrolyte replacement: supplies sodium, potassium, calcium and lactate to correct deficits.
  • Perioperative hydration: maintains euvolemia and acid‑base stability during surgery.

How It Works

  • Lactated Ringer’s solution provides sodium, potassium, calcium, and lactate ions that expand the extracellular fluid compartment. The lactate is metabolized to bicarbonate, helping to correct metabolic acidosis, while the electrolytes support cellular function and osmotic balance, thereby restoring intravascular volume and maintaining acid‑base homeostasis.

Side Effects

Lactated Ringer’s solution may be associated with a range of infusion‑related reactions.

Common Side Effects

  • Mild hypernatremia: slight increase in serum sodium.
  • Mild hyperkalemia: modest rise in serum potassium.
  • Mild hypercalcemia: small elevation of calcium levels.
  • Metabolic alkalosis: due to lactate conversion to bicarbonate.
  • Local irritation at the infusion site.
  • Transient fever or chills.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe hypersensitivity requiring immediate treatment.
  • Pulmonary edema: fluid overload leading to respiratory compromise.
  • Severe electrolyte imbalance: dangerous shifts in sodium, potassium or calcium.
  • Cardiac arrhythmia: rhythm disturbances linked to electrolyte changes.
  • Infection at the catheter site: bacterial contamination of the IV line.
  • Hemolysis: rare red‑cell destruction from improper administration.

Precautions & Warnings

When using Lactated Ringer’s solution, clinicians should observe several safety measures.

  • Assess electrolyte status before administration: verify baseline sodium, potassium, calcium and acid‑base values.
  • Monitor vital signs and fluid balance: track blood pressure, heart rate, urine output and weight.
  • Use caution in renal or cardiac failure: patients may be prone to fluid overload.
  • Avoid rapid infusion in neonates and infants: slower rates reduce risk of circulatory stress.
  • Check compatibility with other IV solutions: incompatibility can cause precipitation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lactated Ringer’s solution can interact with other medications and solutions administered intravenously.

Major Interactions (Avoid)

  • Calcium‑containing solutions with blood products: risk of precipitation and clot formation.
  • Concurrent potassium supplements: may cause dangerous hyperkalemia.
  • Sodium bicarbonate co‑infusion: can lead to severe hypernatremia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increase electrolyte loss, requiring close monitoring.
  • ACE inhibitors or ARBs: heightened risk of hyperkalemia.
  • Beta‑blockers: may amplify hypotensive effects of rapid fluid administration.

Frequently Asked Questions

Lactated Ringer’s Injection Fresenius is an intravenous electrolyte solution used to restore extracellular fluid volume, replace key electrolytes, and maintain acid‑base balance in patients undergoing fluid resuscitation, peri‑operative hydration, or electrolyte replacement therapy.

The solution delivers sodium, potassium, calcium, and lactate ions directly into the bloodstream. Lactate is metabolized to bicarbonate, helping correct metabolic acidosis, while the electrolytes replenish deficits and expand the extracellular fluid compartment, supporting vascular volume and cellular function.

The prescribed dose of Lactated Ringer’s Injection is determined by the treating physician based on the patient’s clinical condition, weight, fluid losses and electrolyte status. Dosing is individualized and administered under medical supervision.

Safety data for Lactated Ringer’s solution in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used when clearly needed and after a risk‑benefit assessment by the healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Unlike normal saline, Lactated Ringer’s contains potassium, calcium and lactate, providing a more physiologic electrolyte composition and helping correct metabolic acidosis. It is often preferred for peri‑operative and trauma resuscitation, whereas normal saline may be chosen when a chloride‑rich solution is specifically required.

Lactated Ringer’s Injection should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain sterility and solution integrity.

The solution is administered intravenously, typically via a peripheral or central venous line. Infusion rate is set by the prescriber according to the patient’s volume status, age, and clinical situation, and the administration should be performed by qualified healthcare personnel.

Serious risks include anaphylactic reactions, severe electrolyte disturbances (hypernatremia, hyperkalemia, hypercalcemia), fluid overload leading to pulmonary edema, and cardiac arrhythmias. Prompt recognition and monitoring are essential to mitigate these complications.

Patients with known hypersensitivity to any component of the solution, those with severe renal or cardiac failure where fluid overload is a concern, and individuals receiving incompatible IV medications (e.g., calcium‑containing blood products) should not be given Lactated Ringer’s unless a risk‑benefit analysis justifies its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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