Jodid Draselný G.L. Pharma (Potassium Iodide)

Potassium Iodide is employed as a thyroid‑blocking agent to reduce radioactive iodine uptake and to address iodine deficiency.

• Radioactive iodine exposure: Provides thyroid protection by blocking uptake of radioactive iodine, reducing radiation dose to the gland.
• Nuclear medicine procedures: Limits thyroid accumulation of iodine‑131 during diagnostic or therapeutic scans, minimizing radiation injury.
• Iodine deficiency prevention: Supplies stable iodide to correct low dietary iodine when used as a supplement.

• Potassium Iodide supplies a stable source of iodide ions that saturate the sodium‑iodide symporter in thyroid follicular cells. By occupying this transporter, it competitively inhibits the uptake of radioactive iodine isotopes such as I‑131, thereby preventing their incorporation into thyroid hormone synthesis and reducing radiation exposure to the gland. The effect persists for several hours, allowing temporary protection during emergencies or medical procedures.

Potassium Iodide may cause adverse reactions, most of which are mild and transient.

Common Side Effects

• Nausea or vomiting
• Metallic taste
• Mild abdominal discomfort

Serious or Rare Side Effects

• Allergic reactions (rash, itching, swelling)
• Anaphylaxis
• Thyrotoxicosis in patients with autonomous thyroid nodules

When using Potassium Iodide, certain precautions should be observed to ensure safety and effectiveness.

• Pregnancy: Use only if clearly needed, as iodine can affect fetal thyroid function.
• Breastfeeding: Evaluate risk‑benefit, as iodide passes into breast milk.
• Pre‑existing thyroid disease: Assess thyroid status before administration.
• Renal impairment: Monitor potassium levels to avoid hyperkalemia.
• Age considerations: Dosage adjustments may be required for children and the elderly.
• Store at below 25°C: Keep in the original container, protect from moisture and direct sunlight.

Potassium Iodide can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

• Lithium: Concurrent use may increase lithium toxicity.
• Thyroid hormones (levothyroxine, liothyronine): May reduce therapeutic effect of thyroid hormone replacement.
• Antithyroid drugs (propylthiouracil, methimazole): Can diminish the intended thyroid‑blocking action.

Moderate Interactions (Monitor Closely)

• Diuretics that affect potassium balance: May exacerbate hyperkalemia risk.
• ACE inhibitors or ARBs: Potential for increased serum potassium.
• Radioactive iodine therapy: Timing must be coordinated to achieve desired blocking effect.