Pylera 120s (Bismuth subcitrate potassium + Metronidazole + Tetracycline hydrochloride Capsule) 140 mg +125 mg +125mg

Pylera 120s is indicated for the eradication of Helicobacter pylori infection in combination with a proton pump inhibitor. This treatment is crucial for managing and preventing the recurrence of peptic ulcers caused by this bacterium.

• Helicobacter pylori infection: Eradicates the bacterium to reduce the risk of peptic ulcer recurrence.
• Peptic ulcers: Helps in the treatment and prevention of ulcers in the stomach and duodenum.
• Gastric inflammation: Reduces inflammation in the stomach lining caused by H. pylori.

• Pylera 120s combines three active ingredients: bismuth subcitrate potassium, metronidazole, and tetracycline hydrochloride. Bismuth subcitrate provides mucosal protection and antimicrobial activity, metronidazole inhibits nucleic acid synthesis in anaerobic bacteria, and tetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. This combination enhances the eradication of Helicobacter pylori and reduces inflammation in the stomach lining.

Pylera 120s may cause various side effects, ranging from common to serious. It is important to be aware of these potential reactions when using this medication.

Common Side Effects

• Diarrhea: May occur during treatment.
• Nausea: A common gastrointestinal side effect.
• Metallic taste: Often reported by patients.
• Abdominal pain: May be experienced during therapy.
• Vomiting: Can occur as a side effect.
• Constipation: May be experienced by some patients.

Serious or Rare Side Effects

• Allergic reactions: Rare but can be severe, including rash, itching, and swelling.
• Stevens-Johnson syndrome: A serious skin reaction that requires immediate medical attention.
• Toxic epidermal necrolysis: A severe skin condition that can be life-threatening.
• QT prolongation: May occur when combined with other medications that affect the heart.
• Liver toxicity: Rare but possible, especially in patients with pre-existing liver conditions.

Pylera 120s should be used with caution, and certain precautions should be observed to ensure safe and effective treatment. Patients should be aware of these precautions before starting therapy.

• Avoid alcohol: Do not consume alcohol during treatment and for at least 24 hours after completing the course.
• Pregnancy: Safety in pregnancy has not been established; consult a healthcare provider before use.
• Breastfeeding: Use with caution; consult a healthcare provider before use.
• Liver disease: Use with caution in patients with liver impairment.
• Kidney disease: Use with caution in patients with kidney impairment.
• Allergic reactions: Discontinue use and seek medical attention if signs of an allergic reaction occur.
• Store below 25°C: Keep in the original pack, protect from moisture.

Pylera 120s may interact with other medications, potentially affecting its efficacy or increasing the risk of side effects. It is important to be aware of these interactions when using this medication.

Major Interactions (Avoid)

• Warfarin: May increase the risk of bleeding due to the interaction with metronidazole.
• Alcohol: Should be avoided during treatment and for at least 24 hours after completing the course.
• Disulfiram: May cause severe reactions when combined with metronidazole.
• Lithium: May increase lithium levels, leading to toxicity.
• Phenytoin: May decrease the effectiveness of phenytoin.

Moderate Interactions (Monitor Closely)

• Oral contraceptives: May reduce the effectiveness of hormonal contraceptives.
• Cyclosporine: May increase cyclosporine levels, leading to toxicity.
• Fluoroquinolones: May increase the risk of central nervous system effects.
• Anticoagulants: May increase the risk of bleeding when combined with metronidazole.