Hidrasec Για Βρεφη (Racecadotril)

Hidrasec Για Βρεφη is indicated for the management of acute, non‑bloody diarrhea in infants and children when rehydration therapy is required.

• Provides symptomatic relief of watery stools in infants.
• Reduces stool frequency and volume.
• Used as an adjunct to oral rehydration solution (ORS) therapy.
• Appropriate when bacterial infection has been excluded.
• May be considered in community‑acquired diarrheal episodes.

• Racecadotril acts as an enkephalinase inhibitor in the intestinal mucosa, preventing the breakdown of endogenous enkephalins. The increased enkephalin levels activate opioid receptors on enteric neurons, which leads to reduced secretion of water and electrolytes into the intestinal lumen, thereby decreasing stool output without affecting intestinal motility.

Side effects of Hidrasec Για Βρεφη are generally mild, but serious reactions can occur in rare cases.

Common

• Mild abdominal pain or discomfort.
• Nausea or transient vomiting.
• Flatulence or bloating.
• Headache.
• Constipation.
• Transient skin rash.

Serious

• Allergic reactions such as urticaria or anaphylaxis.
• Severe skin reactions (e.g., Stevens‑Johnson syndrome).
• Significant hepatic enzyme elevation.
• Persistent severe dehydration despite treatment.

When using Hidrasec Για Βρεφη, caregivers should be aware of several safety considerations.

• Ensure adequate oral rehydration is maintained alongside the medication.
• Do not use for chronic or persistent diarrhea without medical evaluation.
• Avoid use in infants with bloody stools or suspected dysentery.
• Discontinue if signs of allergic reaction appear.
• Use under medical supervision in patients with known hepatic or renal impairment.
• Verify that the child has no known hypersensitivity to racecadotril or formulation excipients.

Potential drug interactions with racecadotril should be considered.

Avoid

• Concomitant use of other antidiarrheal agents such as loperamide.
• Co‑administration with opioid analgesics that may alter gut motility.
• Use with medications that strongly inhibit enkephalinase activity.

Use with caution

• Oral rehydration solutions containing high electrolyte concentrations.
• Antibiotics prescribed for bacterial gastroenteritis.
• Anticholinergic drugs that may increase the risk of constipation.
• Any medication that may affect hepatic metabolism.