Product image of Ramiven 150mg (Abemaciclib) 150mg Tablet supplied by GNH India

Ramiven 150mg

Active Ingredient:
Abemaciclib
Form:
Tablet
Brand:
Ramiven 150mg
Origin:
Spain

Ramiven 150mg (Abemaciclib Tablet) 150mg

Abemaciclib, the active ingredient in Ramiven 150mg, is a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor presented as a 150mg tablet for oral use. It is indicated for the treatment of hormone receptor-positive, HER2-negative advanced or metastatic breast cancer.

GNH India supplies Ramiven 150mg as a licensed, GDP-compliant international pharmaceutical supplier serving oncology centers worldwide.

Strength

150mg

Pack Size

14s

Storage

Ambient

Manufacturer / TM Owner

Lilly S.A

1
Pack/s
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Indications & Clinical Uses

Ramiven 150mg is a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor used in the treatment of breast cancer.

  • Hormone receptor-positive, HER2-negative advanced or metastatic breast cancer: Used in combination with an aromatase inhibitor or fulvestrant as initial endocrine-based therapy or following prior endocrine therapy.
  • Hormone receptor-positive, HER2-negative early breast cancer: Used in combination with endocrine therapy for patients with a high risk of recurrence.

How It Works

  • Abemaciclib selectively inhibits cyclin-dependent kinases 4 and 6 (CDK4/6), which are involved in the regulation of the cell cycle. By inhibiting CDK4/6, abemaciclib prevents the progression of the cell cycle from G1 to S phase, leading to cell cycle arrest and inhibition of tumor cell proliferation.

Side Effects

Ramiven 150mg may cause various side effects, which can be categorized as common or serious.

Common Side Effects

  • Diarrhea
  • Fatigue
  • Nausea
  • Decreased appetite
  • Vomiting
  • Abdominal pain
  • Neutropenia
  • Leukopenia

Serious or Rare Side Effects

  • Interstitial lung disease/pneumonitis
  • Hepatotoxicity
  • Severe neutropenia
  • Febrile neutropenia
  • Venous thromboembolic events
  • Embryo-fetal toxicity

Precautions & Warnings

Ramiven 150mg should be used with caution and certain precautions should be observed.

  • Pregnancy: Avoid use during pregnancy due to potential embryo-fetal toxicity.
  • Breastfeeding: Avoid breastfeeding while taking abemaciclib.
  • Hepatic impairment: Use with caution in patients with hepatic impairment.
  • Renal impairment: Use with caution in patients with renal impairment.
  • Neutropenia: Monitor complete blood counts regularly.
  • Diarrhea: Manage diarrhea promptly and consider dose modifications if severe.
  • Store below 25°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Ramiven 150mg may interact with other medications, which can be categorized as major or moderate.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, phenytoin, carbamazepine)
  • Strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, ritonavir)
  • P-gp inducers (e.g., rifampin, St. John's wort)

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inducers (e.g., efavirenz, modafinil)
  • Moderate CYP3A4 inhibitors (e.g., fluconazole, diltiazem)
  • P-gp inhibitors (e.g., amiodarone, verapamil)

Frequently Asked Questions

Ramiven 150mg is used in the treatment of hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. It is often used in combination with an aromatase inhibitor or fulvestrant as initial endocrine-based therapy or following prior endocrine therapy. Additionally, it may be used in combination with endocrine therapy for patients with early breast cancer who have a high risk of recurrence.

Abemaciclib works by selectively inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6). These kinases are involved in the regulation of the cell cycle. By inhibiting CDK4/6, abemaciclib prevents the progression of the cell cycle from G1 to S phase, leading to cell cycle arrest and inhibition of tumor cell proliferation. This mechanism helps to slow down the growth and spread of cancer cells.

The usual dose of Ramiven 150mg is determined by a healthcare professional based on the patient's condition, response to treatment, and other factors. It is typically taken orally, and the prescriber will set the appropriate dosage and schedule. Always follow the dosage instructions provided by your healthcare provider.

Ramiven 150mg should be avoided during pregnancy due to the potential risk of embryo-fetal toxicity. Women who are pregnant or planning to become pregnant should discuss the risks and benefits with their healthcare provider. Additionally, breastfeeding should be avoided while taking abemaciclib, as it is not known whether the drug passes into breast milk.

To order Ramiven 150mg from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will then provide pricing, availability, shipping details, and the necessary import paperwork.

Ramiven 150mg is a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, which is a targeted therapy for hormone receptor-positive, HER2-negative breast cancer. It is often used in combination with endocrine therapy. Compared to other treatments, such as chemotherapy or other targeted therapies, abemaciclib offers a different mechanism of action that can be beneficial for certain patients. The choice of treatment depends on various factors, including the stage of cancer, the patient's overall health, and the specific characteristics of the tumor.

Ramiven 150mg should be stored below 25°C, in the original pack, and protected from moisture. It is important to keep the medication out of reach of children and to follow the storage instructions provided with the product. Proper storage ensures the stability and effectiveness of the medication.

Ramiven 150mg is administered orally, typically in the form of tablets. The dosage and schedule are determined by a healthcare professional based on the patient's condition and response to treatment. It is important to follow the administration instructions provided by your healthcare provider and to take the medication as prescribed.

The most serious risks associated with Ramiven 150mg include interstitial lung disease/pneumonitis, hepatotoxicity, severe neutropenia, febrile neutropenia, and venous thromboembolic events. Patients should be monitored closely for these potential adverse effects, and any signs or symptoms should be reported to a healthcare provider immediately. Regular blood tests and other monitoring may be required to manage these risks.

Ramiven 150mg should not be used by individuals who are allergic to abemaciclib or any of the excipients in the formulation. It should also be avoided during pregnancy due to the potential risk of embryo-fetal toxicity. Patients with severe hepatic impairment or those taking strong CYP3A4 inducers or inhibitors should use abemaciclib with caution or avoid it altogether. Always consult a healthcare provider to determine if Ramiven 150mg is appropriate for your specific condition.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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