Reconcile

Active Ingredient:: Fluoxetine
Brand:: Reconcile
Origin:: European Union

Reconcile (Fluoxetine)

Fluoxetine, the active ingredient in Reconcile, is a selective serotonin reuptake inhibitor (SSRI) presented as an oral tablet for oral use. It works by increasing serotonin levels in the brain and is indicated for the treatment of major depressive disorder, obsessive‑compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder in adult patients.

GNH India supplies Reconcile as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to quality‑assured medicines across global markets and patients.

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Indications & Clinical Uses

Fluoxetine, an SSRI, acts on serotonergic pathways to alleviate symptoms across several psychiatric and eating‑disorder conditions.

Major depressive disorder: reduces depressive symptoms and improves mood in adults.
Obsessive‑compulsive disorder: lessens intrusive thoughts and compulsive behaviors.
Bulimia nervosa: decreases binge‑eating episodes and associated urges.
Panic disorder: lowers frequency and intensity of panic attacks.
Premenstrual dysphoric disorder: alleviates mood swings and physical discomfort linked to the menstrual cycle.

How It Works

Fluoxetine selectively inhibits the serotonin transporter (SERT) on presynaptic neurons, blocking reuptake of serotonin (5‑HT) into the nerve terminal. This increases extracellular serotonin concentrations, enhancing serotonergic neurotransmission throughout central nervous system pathways involved in mood regulation, anxiety control, and impulse modulation.

Side Effects

Fluoxetine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

Nausea: mild to moderate stomach upset.
Insomnia: difficulty falling or staying asleep.
Headache: transient cranial discomfort.
Dry mouth: reduced salivary flow.
Diarrhea: loose stools.
Sexual dysfunction: decreased libido or delayed orgasm.

Serious or Rare Side Effects

Suicidal thoughts: emergence of suicidal ideation, especially in young adults.
Serotonin syndrome: agitation, hyperthermia, and muscle rigidity.
Hyponatremia: low blood sodium levels causing confusion.
Bleeding risk: increased tendency to bruise or bleed.
Allergic reactions: rash, itching, or swelling.

Precautions & Warnings

Before initiating fluoxetine therapy, consider the following safety measures.

Pregnancy: discuss potential risks with a healthcare professional; data are limited.
Breastfeeding: evaluate infant exposure versus maternal benefit.
Concomitant MAO inhibitors: ensure a minimum 14‑day washout period.
History of bipolar disorder: monitor for mood switching to mania.
Liver or renal impairment: dose adjustment may be required.
Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Fluoxetine can interact with several medication classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome.
Thioridazine: may cause cardiac arrhythmias.
Pimozide: increased risk of QT prolongation.

Moderate Interactions (Monitor Closely)

Warfarin: potential enhancement of anticoagulant effect.
NSAIDs or aspirin: heightened bleeding tendency.
Carbamazepine: may reduce fluoxetine plasma levels.

Frequently Asked Questions

Reconcile contains fluoxetine, an SSRI that is approved for major depressive disorder, obsessive‑compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder in adult patients. It helps improve mood, reduce anxiety, and control compulsive behaviors associated with these conditions.

Fluoxetine blocks the serotonin transporter on presynaptic neurons, preventing reuptake of serotonin into the nerve terminal. This raises serotonin levels in the synaptic cleft, enhancing serotonergic signaling that influences mood, anxiety, and impulse control throughout the central nervous system.

The appropriate dose of Reconcile is determined by the prescribing clinician based on the individual’s diagnosis, severity of symptoms, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for fluoxetine in pregnancy and lactation are limited. Healthcare providers weigh potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss fluoxetine use with their doctor to make an informed decision.

To request Reconcile, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Fluoxetine is an SSRI, a class known for a favorable side‑effect profile compared with older tricyclic antidepressants and monoamine oxidase inhibitors. It has a long half‑life, which may simplify dosing and reduce withdrawal symptoms, but individual response varies, and clinicians choose therapy based on efficacy, tolerability, and patient history.

Reconcile should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and store them out of reach of children.

Reconcile is taken orally, usually once daily, with or without food, as directed by a healthcare professional. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed by a prescriber.

Serious risks include the emergence of suicidal thoughts or behaviors, especially in young adults, serotonin syndrome when combined with other serotonergic agents, severe allergic reactions, and rare cardiac arrhythmias. Patients should seek immediate medical attention if they experience any concerning symptoms.

Fluoxetine is contraindicated in individuals who are currently taking monoamine oxidase inhibitors, have a known hypersensitivity to fluoxetine or any SSRI component, or have a history of severe cardiac conduction abnormalities without proper monitoring. Pregnant or breastfeeding women should consult their physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 29 Jul 2026

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Reconcile (Fluoxetine)

Indications & Clinical Uses

How It Works