Product image of Rexulti-1mg (Brexpiprazole ) 1mg Tablet supplied by GNH India

Rexulti-1mg

Active Ingredient:
Brexpiprazole
Form:
Tablet
Brand:
REXULTI
Origin:
USA

Rexulti-1mg (Brexpiprazole Tablet) 1mg

Brexpiprazole, the active ingredient in Rexulti-1mg, is an atypical antipsychotic presented as a 1mg tablet for oral use. It is used to treat schizophrenia, major depressive disorder (as an adjunct), and agitation associated with dementia due to Alzheimer's disease. GNH India supplies Rexulti-1mg as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Rexulti-1mg is a brand-name medication that is not available as a generic. It is part of the class of drugs known as serotonin-dopamine activity modulators (SDAMs). The medication works by modulating the activity of certain neurotransmitters in the brain, which helps to restore balance and improve symptoms associated with the conditions it treats.

Strength

1mg

Pack Size

30s

Storage

Ambient

Manufacturer / TM Owner

Otsuka America Pharmaceutical, Inc.

1
Pack/s
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Indications & Clinical Uses

Rexulti-1mg is used to treat various mental and mood disorders. It is indicated for the following conditions:

  • Schizophrenia: Helps manage symptoms such as hallucinations, delusions, and disorganized thinking.
  • Major Depressive Disorder (MDD): Used as an adjunctive treatment to improve symptoms of depression when other antidepressants alone are not effective.
  • Agitation associated with dementia due to Alzheimer's disease: Reduces agitation and aggressive behavior in patients with Alzheimer's disease.

How It Works

  • Brexpiprazole works by acting as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptors. This modulation of serotonergic and dopaminergic neurotransmission helps to restore the balance of certain natural substances in the brain, which can improve symptoms of schizophrenia, depression, and agitation associated with dementia.

Side Effects

Rexulti-1mg may cause various side effects, ranging from common to serious. Common Side Effects:

  • Drowsiness: May cause sleepiness or fatigue.
  • Dizziness: May lead to lightheadedness or unsteadiness.
  • Increased appetite: May result in weight gain.
  • Restlessness: May cause an inability to keep still.
  • Shakiness: May lead to tremors or involuntary movements.

Serious or Rare Side Effects

  • Neuroleptic Malignant Syndrome: A rare but serious condition characterized by high body temperature, muscle rigidity, and mental disturbances.
  • Tardive Dyskinesia: Involuntary movements of the face and body that may be irreversible.
  • Increased risk of death in elderly patients with dementia-related psychosis: Should be used with caution in this population.

Precautions & Warnings

Rexulti-1mg should be used with caution and under the supervision of a healthcare provider. Important precautions include:

  • Inform your doctor about all medical conditions: Especially if you have diabetes, high cholesterol, or a history of seizures.
  • Avoid alcohol: May increase the risk of side effects such as drowsiness and dizziness.
  • Monitor for suicidal thoughts: Especially in young adults and adolescents, as antidepressants can increase the risk of suicidal thoughts or behaviors.
  • Use with caution in elderly patients: May increase the risk of stroke or death in elderly patients with dementia-related psychosis.
  • Store at room temperature: Keep away from light and moisture, and store in a place where children and pets cannot access it.

Avoid Interactions

Rexulti-1mg may interact with other medications, which can affect its effectiveness or increase the risk of side effects. Major Interactions (Avoid):

  • Strong CYP3A4 inhibitors: Such as itraconazole and fluoxetine, which can increase the levels of brexpiprazole in the body.
  • Strong CYP3A4 inducers: Such as carbamazepine, which can decrease the levels of brexpiprazole in the body.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines: May increase the risk of sedation and drowsiness.
  • Antihypertensives: May increase the risk of low blood pressure.
  • Anticholinergics: May increase the risk of constipation and dry mouth.

Frequently Asked Questions

Rexulti-1mg is used to treat schizophrenia, major depressive disorder (as an adjunct), and agitation associated with dementia due to Alzheimer's disease. It helps manage symptoms such as hallucinations, delusions, and disorganized thinking in schizophrenia, improves symptoms of depression when used with other antidepressants, and reduces agitation and aggressive behavior in patients with Alzheimer's disease.

Brexpiprazole works by acting as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptors. This modulation of serotonergic and dopaminergic neurotransmission helps to restore the balance of certain natural substances in the brain, which can improve symptoms of schizophrenia, depression, and agitation associated with dementia.

The usual starting dose of Rexulti-1mg is 0.5mg or 1mg once daily. Dosage increases usually occur at weekly intervals until you reach a target dose of 2mg once daily. The maximum recommended daily dose is 3mg. Your doctor may prescribe more or less Rexulti depending on how well you tolerate or respond to it.

It is unknown what effect Rexulti-1mg has on a developing fetus, so it should only be used during pregnancy if the benefits outweigh the risks. It is also not known whether brexpiprazole passes into breast milk, so caution is advised if you are breastfeeding. Always consult your healthcare provider before using any medication during pregnancy or breastfeeding.

To order Rexulti-1mg from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then reply with pricing, availability, shipping, and the import paperwork.

Rexulti-1mg is considered a second-generation version of aripiprazole (Abilify). The effectiveness of Rexulti and Abilify are similar, but Rexulti has slightly different activity at serotonin and dopamine receptors which may reduce some extrapyramidal side effects such as restlessness. It is also not a controlled substance, which may make it more accessible for some patients.

Rexulti-1mg should be stored at room temperature away from light and moisture. It is important to keep all medications away from children and pets. Always follow the storage instructions provided by your pharmacist or on the medication label to ensure the effectiveness and safety of the medication.

Rexulti-1mg is taken orally, usually once daily, with or without food. It is important to take this medication exactly as prescribed by your doctor. Do not increase your dose or take this drug more often than prescribed, as it will not improve your symptoms any faster and may increase your risk of side effects.

The most serious risks to watch for with Rexulti-1mg include Neuroleptic Malignant Syndrome (NMS), which is characterized by high body temperature, muscle rigidity, and mental disturbances, and Tardive Dyskinesia, which involves involuntary movements of the face and body that may be irreversible. It is also important to monitor for suicidal thoughts, especially in young adults and adolescents.

Rexulti-1mg should not be used by individuals who are allergic to brexpiprazole or any of the ingredients in the medication. It should also be used with caution in elderly patients with dementia-related psychosis, as it may increase the risk of stroke or death. Always consult your healthcare provider before starting any new medication to ensure it is safe and appropriate for you.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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