Product image of Nátrium-Citrát Grifols (Sodium Citrate) supplied by GNH India

Nátrium-Citrát Grifols

Active Ingredient:
Sodium Citrate
Origin:
EU

Nátrium-Citrát Grifols (Sodium Citrate)

Sodium citrate, the active ingredient in Nátrium-Citrát Grifols, is an Anticoagulant presented as a sterile solution for intravenous use. It chelates calcium ions, thereby inhibiting clot formation in blood products and during extracorporeal procedures.
GNH India supplies Nátrium-Citrát Grifols as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratorios Grifols, S.A.

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Indications & Clinical Uses

Sodium citrate acts as an anticoagulant and alkalinising agent across several clinical pathways.

  • Blood collection: maintains fluidity of drawn blood for laboratory analysis.
  • Hemodialysis: prevents clotting in the extracorporeal circuit during treatment.
  • Cardiopulmonary bypass: provides anticoagulation while the heart‑lung machine is in use.
  • Urinary alkalinisation: raises urine pH to facilitate excretion of certain drugs or toxins.

How It Works

  • Sodium citrate exerts its effect by binding free calcium ions in plasma, reducing ionised calcium concentration. This chelation interferes with calcium‑dependent steps of the coagulation cascade, preventing fibrin formation. In addition, citrate acts as a weak buffer, contributing to mild metabolic alkalinisation when administered intravenously.

Side Effects

Sodium citrate may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Mild metabolic alkalosis: slight elevation of blood pH.
  • Hypernatremia: increased serum sodium levels.
  • Nausea or vomiting: gastrointestinal discomfort.
  • Headache: transient cranial pain.
  • Local infusion site irritation: redness or mild pain at the catheter site.

Serious or Rare Side Effects

  • Severe hypernatremia: can lead to neurological symptoms.
  • Severe metabolic alkalosis: may cause respiratory depression.
  • Anaphylactic reaction: rare but potentially life‑threatening.
  • Cardiac arrhythmia: due to electrolyte shifts.
  • Hypotension: sudden drop in blood pressure.
  • Renal dysfunction: impaired kidney function in susceptible patients.

Precautions & Warnings

When using sodium citrate, clinicians should observe several safety measures.

  • Renal impairment: monitor serum electrolytes and fluid balance.
  • Cardiac disease: watch for arrhythmias and blood pressure changes.
  • Pregnancy: use only if clearly indicated, weighing maternal benefit against fetal risk.
  • Elderly patients: consider reduced renal clearance and adjust monitoring.
  • Concomitant calcium‑containing medications: avoid additive calcium load that may diminish anticoagulant effect.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Sodium citrate can interact with several drug classes; awareness helps prevent complications.

Major Interactions (Avoid)

  • Calcium‑containing IV solutions: may neutralise citrate’s anticoagulant action.
  • Alkali‑producing agents (e.g., acetazolamide): can exacerbate metabolic alkalosis.
  • Loop diuretics: increase risk of electrolyte imbalance, especially hypocalcaemia.

Moderate Interactions (Monitor Closely)

  • Warfarin or other oral anticoagulants: heightened bleeding risk when combined.
  • ACE inhibitors or ARBs: monitor blood pressure for additive hypotensive effect.
  • Beta‑blockers: observe for excessive bradycardia or hypotension.
  • Other anticoagulants (e.g., heparin): assess coagulation parameters closely.

Frequently Asked Questions

Nátrium-Citrát Grifols contains sodium citrate, which is employed as an anticoagulant in blood collection tubes, during hemodialysis, and in cardiopulmonary bypass procedures. It is also used to alkalinise urine for the enhanced elimination of certain drugs or toxins.

Sodium citrate binds free calcium ions in the bloodstream, lowering ionised calcium levels that are essential for several steps of the coagulation cascade. By reducing calcium availability, it prevents fibrin formation and thus inhibits clot development in extracorporeal circuits and stored blood.

The prescribed dose of sodium citrate is individualized by the treating clinician based on the specific clinical indication, patient weight, renal function, and the intended duration of anticoagulation. No universal dosing regimen is provided; the prescriber sets the appropriate amount.

Sodium citrate should be used in pregnancy or while breastfeeding only when clearly needed and after careful risk‑benefit assessment by the healthcare provider. Limited data exist, so clinicians generally reserve its use for situations where alternative therapies are unsuitable.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Sodium citrate provides reversible anticoagulation by calcium chelation, which can be rapidly neutralised by calcium infusion. Heparin, by contrast, acts through antithrombin activation and has a longer half‑life. Citrate is preferred in extracorporeal circuits where rapid reversal is advantageous, while heparin is often used for systemic anticoagulation.

Store the product at ambient temperature, ideally below 25 °C, in its original packaging. Protect it from moisture, direct sunlight and extreme temperature fluctuations. Ensure that the container remains sealed until use to maintain sterility.

Sodium citrate is administered intravenously, typically as a sterile solution infused into the bloodstream through a catheter or infusion set. The rate and volume are determined by the prescriber according to the clinical context, such as dialysis or cardiopulmonary bypass.

Serious risks include severe hypernatremia, marked metabolic alkalosis, anaphylactic reactions, cardiac arrhythmias, and significant hypotension. Patients should be monitored for electrolyte disturbances and blood pH changes, especially during prolonged infusions.

Sodium citrate is contraindicated in patients with known hypersensitivity to citrate salts, severe hypernatremia, uncontrolled metabolic alkalosis, or those receiving high‑dose calcium supplementation that could neutralise its effect. Caution is also advised for individuals with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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