Product image of Natriumhydrogencarbonat- Lösung Köhler (Sodium Hydrogen Carbonate) supplied by GNH India

Natriumhydrogencarbonat- Lösung Köhler

Active Ingredient:
Sodium Hydrogen Carbonate
Origin:
EU

Natriumhydrogencarbonat- Lösung Köhler (Sodium Hydrogen Carbonate)

Sodium hydrogen carbonate, the active ingredient in Natriumhydrogencarbonat- Lösung Köhler, is an excipient presented as a solution for injection for intravenous use. It provides bicarbonate ions to buffer systemic pH in patients requiring electrolyte management. The product complies with EU pharmacopeial standards and is manufactured under GMP conditions.

GNH India supplies Natriumhydrogencarbonat- Lösung Köhler as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company’s distribution network covers North America, Europe, Asia‑Pacific and the Middle East, ensuring timely delivery to critical care settings.

Manufacturer / TM Owner

Koehler Pharma Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Sodium hydrogen carbonate injection is used to manage disorders of acid‑base balance and electrolyte disturbances.

  • Metabolic acidosis: restores plasma bicarbonate levels to correct systemic acidemia.
  • Renal tubular acidosis: provides bicarbonate to compensate for renal loss of base.
  • Hyperkalemia: promotes intracellular shift of potassium, aiding rapid potassium reduction.
  • Cardiac arrest (ACLS): used as part of resuscitation protocols to counteract acidemia.
  • Certain drug overdoses (e.g., tricyclic antidepressants): alkalinizes urine to enhance drug elimination.

How It Works

  • Sodium hydrogen carbonate dissociates in plasma to release sodium and bicarbonate ions. The bicarbonate acts as a physiological buffer, combining with hydrogen ions to form carbonic acid, which is then converted to carbon dioxide and water for exhalation. This shifts the acid‑base equilibrium toward alkalinity, raising blood pH, while the sodium contributes to extracellular fluid volume and electrolyte balance.

Side Effects

Intravenous administration of sodium hydrogen carbonate may be associated with several adverse reactions.

Common Side Effects

  • Hypernatremia: elevated serum sodium.
  • Metabolic alkalosis: excessive increase in blood pH.
  • Local irritation: pain or erythema at the infusion site.

Serious or Rare Side Effects

  • Severe alkalosis: may cause respiratory depression or seizures.
  • Cardiac arrhythmias: due to rapid potassium shifts.
  • Anaphylactic reaction: rare hypersensitivity.

Precautions & Warnings

When using sodium hydrogen carbonate injection, clinicians should observe several safety considerations.

  • Renal impairment: monitor serum electrolytes and acid‑base status closely.
  • Cardiac disease: avoid rapid infusion in patients with heart failure or arrhythmias.
  • Fluid balance: assess volume status to prevent overload.
  • Concomitant potassium‑lowering agents: watch for profound hypokalemia.
  • Pregnancy and lactation: use only if benefit outweighs potential risk, as data are limited.
  • Store below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Sodium hydrogen carbonate can interact with several medications, altering electrolyte or acid‑base balance.

Major Interactions (Avoid)

  • Insulin therapy: may cause rapid intracellular potassium shift leading to severe hypokalemia.
  • Loop diuretics: additive risk of electrolyte depletion and alkalosis.
  • Sodium‑containing medications: increase risk of hypernatremia and fluid overload.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: monitor for hyperkalemia when used together.
  • Aminoglycoside antibiotics: watch renal function and electrolyte status.
  • Carbonic anhydrase inhibitors (e.g., acetazolamide): may reduce the buffering effect of bicarbonate.

Frequently Asked Questions

Natriumhydrogencarbonat- Lösung Köhler is an intravenous sodium hydrogen carbonate solution used to correct metabolic acidosis, support electrolyte balance, and assist in the management of conditions such as hyperkalemia and certain drug overdoses where plasma pH needs rapid adjustment.

When administered intravenously, sodium hydrogen carbonate dissociates into sodium and bicarbonate ions. Bicarbonate buffers excess hydrogen ions, forming carbonic acid that is quickly converted to carbon dioxide and water, thereby raising blood pH and restoring acid‑base equilibrium.

The appropriate dose of Natriumhydrogencarbonat- Lösung Köhler is determined by the prescribing clinician based on the patient’s acid‑base status, electrolyte levels, weight, and clinical condition. Dosage regimens are individualized and should follow local medical guidelines.

Safety data for sodium hydrogen carbonate injection in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Natriumhydrogencarbonat- Lösung Köhler is a pharmaceutical‑grade sodium hydrogen carbonate solution that meets EU standards for purity and sterility. Compared with generic preparations, it offers consistent concentration, validated GMP manufacturing, and a reliable supply chain through GNH India’s global distribution network.

Store the product below 25°C in its original packaging. Protect it from moisture, direct sunlight, and extreme temperature fluctuations. Do not freeze the solution, and ensure the container remains sealed until use to maintain sterility.

The solution is administered intravenously, typically by slow infusion under aseptic conditions. The rate and volume are adjusted according to the patient’s clinical status and laboratory results, and administration should be performed by qualified healthcare professionals.

Serious risks include severe metabolic alkalosis, which can lead to respiratory depression or seizures, and cardiac arrhythmias caused by rapid shifts in potassium levels. Monitoring of blood gases and electrolytes is essential to detect and manage these complications promptly.

Patients with uncontrolled hypernatremia, severe volume overload, or known hypersensitivity to sodium bicarbonate should not receive this product. Additionally, individuals with certain metabolic disorders where bicarbonate administration is contraindicated should be excluded, as determined by the treating physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Sodium Hydrogen Carbonate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT