Nefrosol Kálium (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc)

Nefrosol Kálium is an intravenous electrolyte solution used in clinical situations that involve fluid loss or electrolyte disturbance.

• Electrolyte replacement: restores sodium, potassium, magnesium and chloride concentrations in patients with depletion.
• Acid‑base balance correction: provides bicarbonate ions to correct metabolic acidosis.
• Fluid resuscitation: delivers isotonic fluid volume to support circulation in hypovolemic states.

• The solution supplies sodium, potassium, magnesium, chloride and bicarbonate ions directly into the bloodstream. These ions replenish depleted extracellular pools, help maintain osmotic balance, support cellular electrical activity, and buffer hydrogen ions to correct acid‑base disturbances, thereby restoring physiological homeostasis during intravenous therapy.

Adverse reactions may occur with any intravenous electrolyte preparation. Monitoring and prompt management are essential.

Common Side Effects

• Mild hypernatremia: elevated serum sodium levels.
• Transient hyperkalemia: temporary increase in potassium.
• Local irritation: pain or erythema at the infusion site.
• Hypocalcemia: reduced calcium levels if calcium content is low.
• Metabolic alkalosis: over‑correction of acidosis.

Serious or Rare Side Effects

• Severe hyperkalemia: cardiac arrhythmia risk.
• Hypermagnesemia: neuromuscular depression.
• Fluid overload: pulmonary edema.
• Severe electrolyte imbalance: neurologic symptoms.
• Anaphylactoid reaction: hypotension and bronchospasm.

Use Nefrosol Kálium only under medical supervision with appropriate laboratory monitoring.

• Assess baseline electrolytes: obtain serum sodium, potassium, magnesium, chloride and bicarbonate before infusion.
• Adjust infusion rate: tailor speed to patient volume status and cardiac function.
• Monitor cardiac rhythm: especially in patients with renal impairment or existing electrolyte abnormalities.
• Avoid rapid correction: prevent osmotic demyelination or sudden shifts in acid‑base balance.
• Contraindications: do not use in patients with known hypersensitivity to any component.
• Store at ambient temperature: keep in original container, protect from light and moisture.

Electrolyte solutions can interact with other medicines that affect ion balance or renal function.

Major Interactions (Avoid)

• ACE inhibitors or ARBs: may potentiate hyperkalemia.
• Digoxin: increased risk of toxicity with elevated potassium.
• Loop diuretics: can cause rapid shifts in sodium and potassium.

Moderate Interactions (Monitor Closely)

• NSAIDs: may impair renal clearance of electrolytes.
• Lithium: altered lithium levels with sodium changes.
• Antacids containing aluminum or magnesium: additive electrolyte load.