Product image of Iodeto De Sódio [i 131] T Curium Netherlands (Sodium Iodide (131i)) supplied by GNH India

Iodeto De Sódio [i 131] T Curium Netherlands

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Iodeto De Sódio [i 131] T Curium Netherlands (Sodium Iodide (131i))

Sodium Iodide (I-131), the active ingredient in Iodeto De Sódio [i 131] T Curium Netherlands, is a radioactive iodine preparation presented as an oral formulation for systemic use. It is employed in the management of thyroid cancer, hyperthyroidism and for thyroid tissue ablation after surgery.

GNH India supplies Iodeto De Sódio [i 131] T Curium Netherlands as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Curium Netherlands B.V.

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Indications & Clinical Uses

  • Iodeto De Sódio (Sodium Iodide I-131) is used in conditions that involve thyroid tissue where radioactive iodine can be taken up.
  • Thyroid cancer: helps destroy residual thyroid cells and metastatic disease after surgery.
  • Hyperthyroidism: reduces overactive thyroid tissue by delivering targeted radiation.
  • Thyroid ablation: eliminates remaining thyroid tissue prior to radioactive iodine therapy or to prepare for hormone replacement.

How It Works

  • Sodium Iodide I-131 is absorbed by thyroid follicular cells via the sodium‑iodide symporter. Once inside the gland, the isotope emits beta particles that cause localized cytotoxic radiation, leading to cellular DNA damage and death, while accompanying gamma emissions allow imaging of iodine uptake.

Side Effects

Adverse reactions may occur following oral administration of radioactive iodine.

Common Side Effects

  • Nausea or upset stomach.
  • Dry mouth or altered taste sensation.
  • Transient neck discomfort or mild thyroiditis.

Serious or Rare Side Effects

  • Bone marrow suppression leading to cytopenias.
  • Severe radiation thyroiditis with significant swelling.
  • Secondary malignancies such as leukemia.
  • Allergic reactions including rash or anaphylaxis.
  • Pulmonary fibrosis (very rare).

Precautions & Warnings

Careful assessment is required before prescribing radioactive iodine.

  • Pregnancy: avoid use unless benefits clearly outweigh risks.
  • Breastfeeding: discontinue treatment and advise cessation of nursing.
  • Renal impairment: monitor renal function and adjust monitoring frequency.
  • Concurrent thyroid hormone therapy: may need dose adjustment.
  • Radiation safety: limit exposure to family members and follow shielding guidelines.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Radioactive iodine can interact with several medications that affect thyroid uptake or radiation exposure.

Major Interactions (Avoid)

  • Thyroid hormone suppressive therapy: may reduce iodine uptake.
  • Lithium: increases retention of I-131 in thyroid tissue.
  • Antithyroid drugs (propylthiouracil, methimazole): block iodine uptake.

Moderate Interactions (Monitor Closely)

  • Diuretics: may alter renal clearance of iodine.
  • ACE inhibitors: require monitoring of renal function.
  • Other radiopharmaceuticals: cumulative radiation dose should be evaluated.

Frequently Asked Questions

Iodeto De Sódio contains Sodium Iodide I-131, a radioactive iodine used to treat thyroid cancer, manage hyperthyroidism, and perform thyroid tissue ablation after surgery. The iodine is selectively taken up by thyroid cells, allowing targeted radiation to destroy abnormal tissue while sparing most other body tissues.

After oral ingestion, Sodium Iodide I-131 is absorbed into the bloodstream and actively transported into thyroid cells by the sodium‑iodide symporter. Inside the gland, the isotope emits beta particles that cause localized radiation damage, leading to cell death, while gamma emissions enable imaging of iodine uptake.

The specific activity and amount of Iodeto De Sódio are determined by the prescribing physician based on the patient’s diagnosis, thyroid size, and prior treatments. Dosing is individualized and calculated in megabecquerels (MBq) or millicuries (mCi) to achieve the therapeutic goal while minimizing exposure.

Radioactive iodine is generally contraindicated in pregnancy because it can cross the placenta and affect the fetal thyroid. Breastfeeding mothers are advised to discontinue nursing for a period recommended by the treating physician, as iodine can be secreted in breast milk and affect the infant’s thyroid function.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and required import documentation.

Compared with antithyroid drugs, radioactive iodine offers a definitive, single‑administration approach that can permanently reduce thyroid activity. Unlike surgical removal, it is non‑invasive and avoids operative risks. However, it may lead to hypothyroidism requiring lifelong hormone replacement, a consideration when choosing therapy.

Iodeto De Sódio should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and handle it according to standard radiation safety guidelines to avoid contamination.

The product is taken orally, usually as a single dose in capsule or liquid form, under the supervision of a qualified physician. Patients may be instructed to fast before and after administration and to follow specific radiation safety precautions for a short period after dosing.

Serious risks include bone marrow suppression, severe radiation thyroiditis, secondary malignancies such as leukemia, and rare pulmonary fibrosis. Patients should be monitored for blood count changes, signs of excessive neck swelling, and any unexpected systemic symptoms following treatment.

Individuals who are pregnant, nursing, or have uncontrolled severe renal impairment should avoid this medication unless the benefits clearly outweigh the risks. Patients with known hypersensitivity to iodine or previous severe reactions to radioactive iodine therapy should also be excluded.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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