Product image of Moniyot-131 Τ Για Θεραπευτική Χρήση (Sodium Iodide (131i)) supplied by GNH India

Moniyot-131 Τ Για Θεραπευτική Χρήση

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Moniyot-131 Τ Για Θεραπευτική Χρήση (Sodium Iodide (131i))

Sodium Iodide-131, the active ingredient in Moniyot-131 Τ Για Θεραπευτική Χρήση, is a radiopharmaceutical presented as a oral formulation for oral use. It treats thyroid cancer, hyperthyroidism and post‑surgical thyroid tissue ablation in patients requiring radioiodine therapy.

GNH India supplies Moniyot-131 Τ Για Θεραπευτική Χρήση as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Monrol Europe Srl

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Indications & Clinical Uses

  • Thyroid cancer: destroys residual thyroid cancer cells after surgery.
  • Hyperthyroidism (Graves' disease): reduces overactive thyroid tissue to restore normal hormone levels.
  • Post‑surgical thyroid tissue ablation: eliminates remaining thyroid tissue to prevent recurrence.

How It Works

  • Sodium Iodide-131 is selectively taken up by thyroid follicular cells via the sodium‑iodide symporter. Once internalized, the isotope emits beta particles that cause localized cytotoxic radiation, leading to selective destruction of hyperfunctioning thyroid tissue and residual cancer cells while sparing surrounding structures.

Side Effects

Common Side Effects

  • Dry mouth: reduced salivary flow after administration.
  • Nausea: mild gastrointestinal upset.
  • Taste alteration: transient metallic taste.

Serious or Rare Side Effects

  • Severe bone marrow suppression: may cause pancytopenia.
  • Radiation thyroiditis: painful inflammation of the thyroid.
  • Secondary malignancies: rare risk of radiation‑induced cancers.
  • Pulmonary fibrosis: rare lung tissue scarring.
  • Severe allergic reaction: anaphylaxis or angioedema.

Precautions & Warnings

Before using Moniyot-131, consider the following precautions.

  • Pregnancy: avoid unless clearly needed; potential fetal radiation exposure.
  • Breastfeeding: contraindicated; drug may be excreted in milk.
  • Renal function: assess kidney performance as excretion may be impaired.
  • Concurrent thyroid hormone therapy: monitor hormone levels after treatment.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Moniyot-131 may interact with several medications.

Major Interactions (Avoid)

  • Antithyroid drugs (e.g., methimazole, propylthiouracil): reduce radioiodine efficacy.
  • Lithium: increases iodine uptake, raising toxicity risk.
  • High iodine diet or iodinated contrast agents: interfere with thyroid uptake.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone replacement: dose may need adjustment post‑therapy.
  • Chemotherapeutic agents causing bone marrow suppression: monitor blood counts.
  • ACE inhibitors: no direct effect, but monitor renal function during treatment.

Frequently Asked Questions

Moniyot-131 is a radioiodine preparation used to treat thyroid cancer, manage hyperthyroidism such as Graves' disease, and ablate residual thyroid tissue after surgery. It delivers targeted radiation to thyroid cells, helping to eliminate disease‑causing tissue while preserving surrounding structures.

Sodium Iodide-131 is taken up by thyroid cells through the sodium‑iodide symporter. Inside the cell, the isotope emits beta radiation that destroys the cell’s DNA, leading to selective removal of hyperfunctioning or malignant thyroid tissue without affecting most other body tissues.

The dose of Moniyot-131 is individualized and determined by the prescribing physician based on the specific indication, disease severity, and patient characteristics. No standard dose is provided here; clinicians calculate the activity required for each case.

Moniyot-131 is generally contraindicated in pregnancy because the radiation can affect the developing fetus. Breastfeeding is also discouraged, as the drug may be secreted in breast milk. Use only if the potential benefit outweighs the risk and after thorough risk assessment.

To order Moniyot-131, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with surgical removal or antithyroid drugs, Moniyot-131 offers a non‑invasive option that selectively targets thyroid tissue. It avoids the risks of anesthesia and surgery, but requires careful dosing and monitoring for radiation‑related effects. Choice of therapy depends on disease stage, patient preference and clinical guidelines.

Moniyot-131 should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect the product from moisture, direct sunlight and physical damage. Follow all local regulations for handling radiopharmaceuticals, and ensure that only authorized personnel manage the material.

Moniyot-131 is administered orally as a single dose, usually in capsule or liquid form, under the supervision of a qualified healthcare professional. Patients may be instructed to avoid certain foods or medications before and after dosing to optimize thyroid uptake.

Serious risks include severe bone marrow suppression, which can lead to pancytopenia, radiation‑induced thyroiditis, and the rare possibility of secondary malignancies. Patients should be monitored closely for blood count changes and any signs of acute inflammation after treatment.

Moniyot-131 should not be used in patients who are pregnant, breastfeeding, have severe renal impairment, or have a known hypersensitivity to iodine or radiopharmaceuticals. Additionally, individuals with uncontrolled thyroid disorders that require immediate surgical intervention may be unsuitable candidates.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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