Product image of Lactated Ringer’s Injection Fresenius (Sodium Lactate Solution, Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate) supplied by GNH India

Lactated Ringer’s Injection Fresenius

Active Ingredient:
Sodium Lactate Solution, Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate
Origin:
EU

Lactated Ringer’s Injection Fresenius (Sodium Lactate Solution, Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate)

Sodium lactate, the active ingredient in Lactated Ringer’s Injection, is an electrolyte solution presented as a 3 g/L sodium lactate injection solution for intravenous use. It restores extracellular fluid volume and corrects metabolic acidosis in patients requiring fluid resuscitation, peri‑operative care, or dehydration management.

GNH India supplies Lactated Ringer’s Injection as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Hellas Single Member S.A.

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Indications & Clinical Uses

Lactated Ringer’s solution is used as an isotonic electrolyte fluid for volume expansion and electrolyte replacement.

  • Fluid resuscitation: restores intravascular volume in hypovolemic patients.
  • Perioperative fluid management: maintains hemodynamic stability during surgery.
  • Treatment of dehydration: replaces lost fluids and electrolytes.
  • Correction of metabolic acidosis: provides lactate that is metabolized to bicarbonate.
  • Electrolyte replacement: supplies sodium, potassium, calcium, and chloride to correct imbalances.

How It Works

  • Lactated Ringer’s Injection delivers an isotonic mixture of sodium, potassium, calcium, and chloride ions together with lactate. The lactate is metabolized by the liver to bicarbonate, helping to buffer acidic blood. The balanced electrolyte composition expands extracellular fluid volume, corrects electrolyte deficits, and supports normal cellular function during fluid loss or surgery.

Side Effects

Common Side Effects

  • Mild hyperkalemia: slight increase in serum potassium.
  • Transient hypertension: temporary rise in blood pressure.
  • Local irritation: discomfort at the intravenous site.
  • Nausea: occasional feeling of nausea.

Serious or Rare Side Effects

  • Fluid overload: risk of pulmonary edema in susceptible patients.
  • Severe hypernatremia: excessive sodium leading to neurologic symptoms.
  • Allergic reaction: anaphylaxis or severe hypersensitivity.

Precautions & Warnings

Lactated Ringer’s Injection should be administered with careful clinical assessment.

  • Assess volume status: evaluate patient’s fluid balance before administration.
  • Monitor electrolytes: check serum sodium, potassium, and calcium levels during therapy.
  • Use caution in renal failure: adjust volume to avoid overload.
  • Avoid in severe heart failure: risk of exacerbating cardiac dysfunction.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lactated Ringer’s Injection may interact with other medications affecting fluid and electrolyte balance.

Major Interactions (Avoid)

  • Concurrent hypertonic saline: may cause severe hypernatremia.
  • High-dose potassium supplements: risk of hyperkalemia.
  • Calcium channel blockers: can potentiate calcium load.

Moderate Interactions (Monitor Closely)

  • Diuretics: may alter electrolyte balance, requiring monitoring.
  • ACE inhibitors: can affect potassium levels.
  • NSAIDs: may impair renal function, increasing risk of fluid overload.

Frequently Asked Questions

Lactated Ringer’s Injection is an isotonic electrolyte solution used to restore extracellular fluid volume, replace lost electrolytes, and correct metabolic acidosis. It is commonly employed in fluid resuscitation, peri‑operative fluid management, and treatment of dehydration.

Sodium lactate in the solution is metabolized by the liver into bicarbonate, which helps buffer acidic blood. The balanced electrolytes (sodium, potassium, calcium, chloride) expand the extracellular fluid compartment and correct electrolyte disturbances.

The dose of Lactated Ringer’s Injection is determined by the prescribing clinician based on the patient’s volume status, weight, and clinical condition. The healthcare professional selects the appropriate infusion rate and total volume.

The safety of Lactated Ringer’s Injection in pregnancy or while breastfeeding has not been definitively established. Clinicians should weigh potential benefits against any unknown risks and consider alternative fluids if appropriate.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Unlike normal saline, Lactated Ringer’s Injection contains potassium, calcium, and lactate, providing a more physiologic electrolyte composition and the ability to buffer metabolic acidosis. Normal saline lacks these ions and may lead to hyperchloremic acidosis when used in large volumes.

Lactated Ringer’s Injection should be stored at 2‑8 °C. Keep the product refrigerated, protect it from light, and avoid freezing or shaking the container to maintain solution stability.

The solution is administered intravenously, typically via a peripheral or central line. It is infused as a continuous drip or bolus, according to the clinician’s prescription and the patient’s clinical needs.

Serious risks include fluid overload leading to pulmonary edema, severe hypernatremia, and rare allergic reactions such as anaphylaxis. Patients with heart failure, renal impairment, or electrolyte disorders require close monitoring.

Patients with known hypersensitivity to any component, severe congestive heart failure, uncontrolled hyperkalemia, or severe renal impairment where fluid overload is a concern should avoid Lactated Ringer’s Injection unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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