Laxoberal Abführ-Tropfen (Sodium Picosulfate Monohydrate)

Sodium picosulfate monohydrate is used as a stimulant laxative to relieve constipation.

• Constipation: promotes bowel movements in patients with functional constipation.
• Bowel preparation: assists in cleansing the colon before diagnostic procedures such as colonoscopy.
• Irritable bowel syndrome with constipation: helps alleviate the constipation component of IBS-C.

• Sodium picosulfate monohydrate is a prodrug that is metabolized by colonic bacteria into an active sulfated compound. The metabolite stimulates the enteric nervous system, increasing peristaltic activity and fluid secretion in the colon, which facilitates the passage of stool and produces a laxation effect.

Adverse reactions may occur with use of sodium picosulfate monohydrate oral drops.

Common Side Effects

• Abdominal cramps: mild to moderate discomfort in the lower abdomen.
• Diarrhea: loose stools occurring shortly after administration.
• Nausea: feeling of queasiness without vomiting.
• Flatulence: increased intestinal gas.
• Thirst: sensation of dry mouth.
• Headache: mild headache during the laxation period.

Serious or Rare Side Effects

• Severe electrolyte imbalance: abnormal sodium or potassium levels requiring medical attention.
• Dehydration: excessive fluid loss leading to dizziness or weakness.
• Allergic reaction: rash, itching, or swelling of the face, lips, or tongue.
• Colitis: inflammation of the colon presenting with severe abdominal pain.
• Rectal bleeding: visible blood in stool indicating mucosal injury.
• Anaphylaxis: rare life‑threatening hypersensitivity reaction.

Before using sodium picosulfate monohydrate oral drops, consider the following precautions.

• Assess renal function: adjust use in patients with impaired kidney function.
• Monitor electrolyte balance: prolonged therapy may disturb sodium or potassium levels.
• Avoid in intestinal obstruction: risk of perforation or worsening blockage.
• Use with caution in the elderly: increased sensitivity to stimulant effects.
• Pregnancy and lactation: consult a healthcare professional before use.
• Store at ambient temperature: keep in the original container, protect from moisture and light.

Sodium picosulfate monohydrate may interact with other medicines.

Major Interactions (Avoid)

• Anticholinergic drugs: may reduce the laxative efficacy.
• Opioid analgesics: can counteract the stimulant effect on bowel motility.
• Lithium: risk of altered lithium serum concentrations.

Moderate Interactions (Monitor Closely)

• Antidiarrheal agents (e.g., loperamide): may diminish the intended laxation.
• Magnesium‑containing antacids: additive laxative effect may increase stool frequency.
• Diuretics: may heighten the risk of dehydration and electrolyte loss.