Tenoheal-300 (Tenofovir Disoproxil Fumarate Tablet) 300mg

Tenoheal-300 is an antiviral medication used to treat infections caused by viruses that rely on reverse transcriptase for replication. It is primarily indicated for the following conditions:

• HIV-1 infection: Reduces the amount of HIV in the body, helping the immune system recover and lowering the risk of developing AIDS-related complications.
• Chronic hepatitis B infection: Helps prevent liver damage, cirrhosis, and liver cancer by stopping the virus from attacking liver cells.

• Tenofovir disoproxil fumarate works by inhibiting the activity of HIV reverse transcriptase, an enzyme essential for viral replication. It competes with natural substrates and causes chain termination of viral DNA synthesis, thereby preventing the virus from multiplying. This mechanism helps to reduce the viral load in the body and supports the immune system.

Tenoheal-300 may cause various side effects, ranging from common to serious or rare. It is important to be aware of these potential effects when using the medication.

Common Side Effects

• Nausea or vomiting
• Diarrhea
• Dizziness or headache
• Rash
• Fatigue

Serious or Rare Side Effects

• Kidney problems, including renal impairment
• Bone density loss, which may lead to osteoporosis or fractures
• Lactic acidosis, a serious condition caused by a buildup of lactic acid in the body
• Severe worsening of hepatitis B infection if the medication is stopped abruptly

Tenoheal-300 should be used with caution and under the supervision of a healthcare professional. Important precautions include:

• Kidney function: Regular blood tests are required to monitor kidney health, as long-term use may affect renal function.
• Bone health: This medication may cause a decrease in bone mineral density, so calcium and Vitamin D supplementation may be recommended.
• Lactic acidosis: Seek immediate medical help if you experience unusual muscle pain, stomach pain, or extreme weakness, as these could be signs of lactic acidosis.
• HBV flare-up: If you have hepatitis B, do not stop this medication abruptly, as it can cause a severe worsening of the infection.
• Store below 25°C: Keep in the original pack, protect from moisture.

Tenoheal-300 may interact with other medications, which can affect its efficacy or increase the risk of side effects. It is important to inform your healthcare provider about all the medications you are taking.

Major Interactions (Avoid)

• Didanosine: Concurrent use may increase the risk of serious side effects, including pancreatitis and lactic acidosis.
• Atazanavir: May reduce the effectiveness of atazanavir, leading to treatment failure.
• Ledipasvir/sofosbuvir: May increase the risk of side effects, including kidney problems.

Moderate Interactions (Monitor Closely)

• Other antiretroviral medications: May require dose adjustments or close monitoring to avoid adverse effects.
• Drugs that affect kidney function: May increase the risk of kidney-related side effects.