Product image of Nervobión 5000 (Thiamine Hydrochloride, Cyanocobalamin, Pyridoxine Hydrochloride) supplied by GNH India

Nervobión 5000

Active Ingredient:
Thiamine Hydrochloride, Cyanocobalamin, Pyridoxine Hydrochloride
Origin:
EU

Nervobión 5000 (Thiamine Hydrochloride, Cyanocobalamin, Pyridoxine Hydrochloride)

Thiamine Hydrochloride, Cyanocobalamin and Pyridoxine Hydrochloride, the active ingredients in Nervobión 5000, are a vitamin B complex presented as an injectable formulation for intramuscular use. They are employed to correct deficiencies of vitamin B1, B6 or B12 in patients at risk of conditions such as beriberi, peripheral neuropathy or pernicious anemia.

GNH India supplies Nervobión 5000 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company ensures quality compliance with EU standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Laboratorios Vicks, S.L.

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Indications & Clinical Uses

Nervobión 5000 provides essential B‑vitamins and is used in clinical situations involving impaired carbohydrate metabolism or nerve function.

  • Beriberi (thiamine deficiency): restores thiamine levels to improve energy metabolism and prevent cardiac and neurological complications.
  • Pernicious anemia (vitamin B12 deficiency): supplies cyanocobalamin to support red blood cell formation and neurological health.
  • Pyridoxine deficiency: delivers pyridoxine to aid amino‑acid metabolism and reduce symptoms of peripheral neuropathy.

How It Works

  • Thiamine (B1) participates in pyruvate dehydrogenase and transketolase, facilitating carbohydrate oxidation. Pyridoxine (B6) is required for transamination, decarboxylation and glycogenolysis. Cyanocobalamin (B12) is essential for methionine synthase and methylmalonyl‑CoA mutase, supporting DNA synthesis and myelin formation. Intramuscular delivery bypasses gastrointestinal absorption, ensuring rapid bioavailability.

Side Effects

Adverse reactions to intramuscular vitamin B complex injections are generally uncommon but may occur.

Common Side Effects

  • Injection site pain: mild discomfort or soreness at the injection site.
  • Redness or swelling: localized erythema or edema.
  • Low‑grade fever: transient temperature rise within 24 hours.
  • Headache: mild to moderate headache.
  • Nausea: occasional upset stomach.
  • Dizziness: brief sensation of light‑headedness.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Serum sickness‑like reaction: fever, rash and arthralgia occurring days after injection.
  • Thrombophlebitis: inflammation of the vein at the injection site.
  • Severe hypotension: sudden drop in blood pressure.
  • Neurological worsening: unexpected increase in neuropathic symptoms.
  • Persistent vomiting: prolonged emesis requiring treatment.

Precautions & Warnings

Before administering Nervobión 5000, several precautions should be observed to ensure patient safety.

  • Assess vitamin status: verify B‑vitamin deficiency through laboratory testing.
  • Monitor for hypersensitivity: observe for signs of allergic reaction during and after injection.
  • Use with caution in renal impairment: adjust monitoring as excretion may be altered.
  • Avoid in known allergy to any component: contraindicated if patient has hypersensitivity to thiamine, cyanocobalamin or pyridoxine.
  • Pregnancy and lactation: safety not established; weigh potential benefits against risks.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nervobión 5000 may interact with certain medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Cisplatin: concurrent use may exacerbate neurotoxicity.
  • Isoniazid: can mask thiamine deficiency, leading to delayed diagnosis.
  • Levodopa: high doses of pyridoxine may diminish levodopa effectiveness.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may alter plasma levels of B‑vitamins.
  • Anticonvulsants (phenytoin, carbamazepine): increase metabolism of B‑vitamins, potentially reducing therapeutic effect.
  • Metformin: long‑term use can impair vitamin B12 absorption, requiring closer monitoring.

Frequently Asked Questions

Nervobión 5000 is indicated for the correction of documented deficiencies of vitamin B1 (thiamine), vitamin B6 (pyridoxine) or vitamin B12 (cyanocobalamin). It is commonly used in patients with beriberi, pernicious anemia, or other clinical states where low levels of these B‑vitamins lead to metabolic or neurological disturbances.

Thiamine, pyridoxine and cyanocobalamin each serve as essential co‑factors for enzymes involved in carbohydrate metabolism, amino‑acid processing and DNA synthesis. By supplying these vitamins directly into the muscle, the formulation bypasses intestinal absorption, rapidly restoring intracellular co‑factor levels and supporting normal energy production, nerve function and red‑cell formation.

The dose of Nervobión 5000 is individualized by the prescribing clinician based on the patient’s specific vitamin deficiency, severity of symptoms, laboratory results and overall clinical condition. The prescriber decides the volume and frequency of intramuscular injection, which may vary from a single loading dose to a series of maintenance injections.

Safety data for intramuscular vitamin B‑complex injections in pregnancy and lactation are limited. The product should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified health‑care professional.

To place an order, visit the product page on gnhindia.com, enter the required quantity and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and any necessary import documentation.

Nervobión 5000 delivers three B‑vitamins in a single intramuscular injection, offering rapid bioavailability compared with oral tablets that may be poorly absorbed in certain patients. It can be more convenient than administering separate injections for each vitamin, but oral high‑dose formulations remain an alternative for patients without absorption issues.

Store Nervobión 5000 at ambient temperature, preferably below 25 °C. Keep the vials in their original packaging, protect them from moisture and direct sunlight, and avoid freezing. Follow any additional handling instructions provided on the label to maintain product integrity.

Nervobión 5000 is administered by a qualified health‑care professional as an intramuscular injection, typically into the deltoid or gluteal muscle. The injection site should be cleaned with an antiseptic, and the appropriate volume drawn into a sterile syringe before administration according to aseptic technique.

The most serious adverse events include anaphylactic or severe allergic reactions, serum‑sickness‑like responses, thrombophlebitis at the injection site, sudden hypotension and unexpected worsening of neurological symptoms. Patients should be monitored closely after injection, and any signs of severe reaction require immediate medical attention.

Nervobión 5000 is contraindicated in individuals with known hypersensitivity to thiamine, cyanocobalamin, pyridoxine or any excipients in the formulation. It should also be avoided in patients with a history of severe allergic reactions to injectable vitamins until a risk‑benefit assessment is performed by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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