Product image of Tiopronin 100mg Tablet supplied by GNH India

Tiopronin

Active Ingredient:
Tiopronin
Form:
Tablet
Brand:
Tiopronin
Origin:
USA

Tiopronin (Tablet) 100mg

Tiopronin, the active ingredient in Tiopronin, is a thiol-containing drug presented as a 100mg tablet for oral use. It is used to prevent cystine kidney stones in patients with cystinuria.

GNH India supplies Tiopronin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

100mg

Pack Size

100s

Storage

Below 25°C

Manufacturer / TM Owner

Teva

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Tiopronin is a cystine-lowering agent used to manage cystinuria, a condition that causes the formation of cystine kidney stones.

  • Cystinuria: Helps prevent the formation of cystine kidney stones by increasing the solubility of cystine in urine.
  • Severe homozygous cystinuria: Used in patients with severe forms of cystinuria to reduce the risk of stone formation.
  • Cystine stone prevention: Effective in patients who have shown severe toxicity to other treatments like D-penicillamine.

How It Works

  • Tiopronin works by forming a mixed disulfide with cysteine, which increases the solubility of cystine in urine. This action helps to prevent the formation of cystine kidney stones by reducing the concentration of cystine in the urine.

Side Effects

Tiopronin may cause various side effects, ranging from common to serious.

Common Side Effects

  • Nausea: Mild to moderate nausea is a frequent side effect.
  • Vomiting: Some patients may experience vomiting.
  • Diarrhea: Loose stools or diarrhea can occur.
  • Rash: Skin rashes may develop in some individuals.
  • Fever: Mild fever is a possible side effect.
  • Dizziness: Some patients may feel dizzy.
  • Fatigue: General tiredness or weakness can be experienced.

Serious or Rare Side Effects

  • Hepatotoxicity: Severe liver damage is a rare but serious side effect.
  • Nephrotoxicity: Kidney damage can occur in some cases.
  • Bone marrow suppression: Rarely, it may affect bone marrow function.
  • Hypersensitivity reactions: Severe allergic reactions can occur.
  • Aplastic anemia: A rare but serious blood disorder.

Precautions & Warnings

Tiopronin should be used with caution and under medical supervision.

  • Pregnancy: Avoid use during pregnancy unless clearly needed.
  • Breastfeeding: Use with caution and only if necessary.
  • Liver disease: Monitor liver function regularly.
  • Kidney disease: Use with caution in patients with kidney problems.
  • Blood disorders: Regular blood tests are recommended.
  • Allergies: Inform your doctor if you have any known allergies.
  • Store at 25°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Tiopronin may interact with other medications, potentially affecting its efficacy or increasing the risk of side effects.

Major Interactions (Avoid)

  • Gold salts: Avoid concurrent use due to increased risk of side effects.
  • Penicillamine: Avoid using together to prevent adverse reactions.
  • Iron supplements: Avoid concurrent use to prevent interactions.
  • Copper supplements: Avoid using together to prevent interactions.
  • Zinc supplements: Avoid concurrent use to prevent interactions.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: Monitor closely for increased bleeding risk.
  • Diuretics: Monitor for changes in electrolyte balance.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs): Monitor for increased risk of side effects.
  • Antacids: Monitor for reduced effectiveness of tiopronin.
  • Multivitamins: Monitor for potential interactions with mineral supplements.

Frequently Asked Questions

Tiopronin is used to prevent cystine kidney stones in patients with cystinuria. It works by increasing the solubility of cystine in urine, reducing the risk of stone formation. This medication is particularly important for individuals with severe homozygous cystinuria, where other treatments may not be effective or may cause severe toxicity.

Tiopronin works by forming a mixed disulfide with cysteine, which increases the solubility of cystine in urine. This action helps to prevent the formation of cystine kidney stones by reducing the concentration of cystine in the urine. By making cystine more soluble, Tiopronin effectively lowers the risk of stone formation in patients with cystinuria.

The dosage of Tiopronin is determined by a healthcare provider based on the patient's specific needs and medical history. It is important to follow the prescribed dosage and instructions provided by your doctor. The dosage may be adjusted over time to achieve the best therapeutic effect while minimizing side effects.

Tiopronin should be avoided during pregnancy unless clearly needed. If you are pregnant or planning to become pregnant, discuss the potential risks and benefits with your healthcare provider. Similarly, use tiopronin with caution while breastfeeding, as it may pass into breast milk. Consult your doctor for personalized advice.

To order Tiopronin from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will then provide pricing, availability, shipping details, and the necessary import paperwork.

Tiopronin is often used as an alternative to D-penicillamine in patients who experience severe toxicity or adverse reactions to D-penicillamine. Both medications are used to prevent cystine kidney stones, but tiopronin may be better tolerated in some individuals. Your healthcare provider will determine the most suitable treatment based on your specific medical history and needs.

Tiopronin should be stored at 25°C (77°F), with excursions permitted to 15-30°C (59-86°F). Keep the medication in the original pack and protect it from moisture. Follow the storage instructions provided with the medication to ensure its effectiveness and safety. Always store tiopronin out of reach of children and pets.

Tiopronin is administered orally in tablet form. The tablets should be taken exactly as prescribed by your healthcare provider. It is important to follow the dosage and administration instructions provided by your doctor to achieve the best therapeutic effect. Do not crush or chew the tablets unless instructed to do so.

The most serious risks associated with Tiopronin include hepatotoxicity (liver damage), nephrotoxicity (kidney damage), bone marrow suppression, hypersensitivity reactions, and aplastic anemia. Regular monitoring and follow-up with your healthcare provider are essential to detect and manage these potential risks early.

Tiopronin is not suitable for everyone. You should not take Tiopronin if you are pregnant or breastfeeding unless clearly needed. Additionally, individuals with known allergies to tiopronin or any of its components should avoid this medication. Always consult your healthcare provider to determine if Tiopronin is appropriate for your specific medical condition.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Tiopronin

Tiopronin 100 mg/1

Tiopronin 100 mg/1

100 mg/1 TABLET, SUGAR COATED
Thiola 100 mg/1

Thiola 100 mg/1

100 mg/1 TABLET, SUGAR COATED
Thiola EC 300 mg/1

Thiola EC 300 mg/1

300 mg/1 TABLET, DELAYED RELEASE
Thiola EC 100 mg/1

Thiola EC 100 mg/1

100 mg/1 TABLET, DELAYED RELEASE

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT